国家自然科学基金(81102464)

作品数：5被引量：19H指数：3
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相关作者：赵午莉宋丹青李阳彪邵荣光毕重文更多>>
相关机构：中国医学科学院北京协和医学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《中国医药导报》《Acta Pharmaceutica Sinica B》《医学研究杂志》更多>>
相关主题：抗肿瘤PHOSPHORYLATION白血病构效关系活性研究更多>>
相关领域：医药卫生更多>>
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The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells被引量：3
《Acta Pharmaceutica Sinica B》2022年第1期210-227,共18页Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao 
supported by the National Key Research and Development Program of China(2016YFA0201504);National Natural Science Foundation of China(No.81473249 and81102464);the National Mega-project for Innovative Drugs(2014ZX09201042,China);the CAMS Innovation Fund for Medical Sciences(CIFMS,2016-I2M-2-002,China);Drug Innovation Major Project of China(2018ZX09711001-007-002)。
Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural com...
关键词：Pancreatic cancer Secoemestrin C YAP degradation ER stress inducer Resistance Fast shrinkage YAP destruction complex Lipid droplet formation 
G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin被引量：6
《Acta Pharmacologica Sinica》2021年第11期1900-1912,共13页Cong-hui Zhang Hong Liu Wu-li Zhao Wen-xia Zhao Hui-min Zhou Rong-guang Shao 
supported by the National Key Research and Development Program of China(2016YFA0201504);National Natural Science Foundation of China(No.81673471,81102464);the CAMS Initiative for Innovative Medicine(2016-I2M-2-002);the Drug Innovation Major Project of China(2018ZX09711001-007-002).
Ras-GTPase activating SH3 domain-binding protein 1(G3BP1)is a multifunctional binding protein involved in the development of a variety of human cancers.However,the role of G3BP1 in breast cancer progression remains la...
关键词：G3BP1 Wnt/β-catenin signaling pathway GSK-3βphosphorylation protein stability breast cancer peptide antagonist 
The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation
《Acta Pharmacologica Sinica》2020年第5期686-697,共12页Wu-li Zhao Yan Xing Cheng Ye Yu-han Qiu Yi Li Xiu-jun Liu Meng-yan Wang Chong-wen Bi Dan-qing Song Rong-guang Shao 
the National Key Research and Development Program of China(2016YFA0201504);National Natural Science Foundation of China(Nos.81473249 and 81102464);the National Mega-project for Innovative Drugs(2014ZX09201042);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-2-002);Drug Innovation Major Project of China(2018ZX09711001-007-002).
Sophoridine is a quinolizidine natural product and the exploration of its derivatives has been carried out,and the potent anticancer compound IMB-HDC was acquired.Although previous studies have revealed that some soph...
关键词：DNA breakage STAT5a SHUTTLE ANTICANCER nuclear location 
环化小檗碱类似物A55的抗肿瘤活性及其机制研究被引量：2
《医学研究杂志》2014年第5期15-18,共4页赵午莉 李阳彪 何红伟 宋丹青 邵荣光 
国家自然科学基金资助项目(81102464);国家重大新药创新科技重大专项基金资助项目(20122X09301002-001)
目的研究环化小檗碱衍生物(CBBR)A55的抗肿瘤活性及其初步抗肿瘤机制。方法利用磺酰罗丹明B(SRB)法来检测化合物的抑瘤率和半数抑制浓度(IC50),采用流式细胞分析法来检测细胞周期分布,采用拓扑异构酶抑制实验来检测A55对拓扑异构酶Ⅰ活...
关键词：抗肿瘤 拓扑异构酶 DNA断裂 凋亡 环化小檗碱类似物A55 
13-取代小檗碱衍生物的合成及其抗肿瘤活性研究被引量：8
《中国医药导报》2013年第18期17-20,共4页赵午莉 李阳彪 李迎红 汪燕翔 毕重文 邵荣光 宋丹青 
国家自然科学基金资助项目(编号81102464);国家重点基础研究发展计划(973计划)课题(编号2009CB521807)
目的通过在小檗碱的13位上引入不同取代基,探讨13-取代小檗碱衍生物的体外抗肿瘤活性构效关系,并对其抗肿瘤作用机制开展初步研究。方法以小檗碱为起始原料,13-烷基小檗碱(3a-3j)可经选择性还原后与脂肪醛反应而制备;13-取代苄基小檗碱(...
关键词：13-取代小檗碱 抗肿瘤 构效关系 白血病 
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