国家自然科学基金(30900678)

作品数:1被引量:6H指数:1
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相关期刊:《Acta Pharmacologica Sinica》更多>>
相关主题:MRP2ERKCHOLESTASISPKOXIDATIVE_STRESS更多>>
相关领域:医药卫生更多>>
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Rifampicin induces clathrin-dependent endocytosis and ubiquitin–proteasome degradation of MRP2 via oxidative stress-activated PKC-ERK/JNK/p38 and PI3K signaling pathways in HepG2 cells被引量:6
《Acta Pharmacologica Sinica》2020年第1期56-64,共9页Bao-yan Xu Xu-dong Tang Jing Chen Hong-bo Wu Wen-sheng Chen Lei Chen 
the National Natural Science Foundation of China(Nos.81470850 and 30900678);the Key Project of Science and Technology of Chongqing(CSTC,2009BB5159).
It was reported that antituberculosis medicines could induce liver damage via oxidative stress.In this study,we investigated the effects of rifampicin(RFP)on the membrane expression of multidrug resistance-associated ...
关键词:RIFAMPICIN CHOLESTASIS MRP2 oxidative stress PKC-ERK/JNK/p38 PI3K endocytosis CHOLESTASIS HepG2 cells 
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