国家自然科学基金(30900646)

作品数:3被引量:1H指数:1
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相关作者:董慧张永鹤王奇敏王广发张成更多>>
相关机构:北京大学第一医院北京大学更多>>
相关期刊:《Chinese Medical Journal》《中国应用生理学杂志》《Neuroscience Bulletin》更多>>
相关主题:POTASSIUM_CHANNELDORSALVAGALPH-SENSITIVEHYPEREXCITABILITY更多>>
相关领域:医药卫生生物学机械工程更多>>
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自由活动大鼠睡眠呼吸监测技术改进
《中国应用生理学杂志》2014年第1期27-30,共4页王奇敏 董慧 张成 张永鹤 马靖 王广发 
国家自然科学基金(30900646)
目的:改进大鼠睡眠呼吸监测技术,解决既往模型中咬线、脱落、信号不稳定问题。方法:改进监测电极、信号接入线路及动物手术。结果:改进后手术时间缩短,创面暴露时间减少,大鼠术后易恢复。且电极稳固性好,脑电和肌电信号更稳定清晰,信号...
关键词:睡眠 监测 大鼠 
Inhibition of central Na+/H+ exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats
《Chinese Medical Journal》2014年第1期48-53,共6页Wang Qimin Zhou Rong Zhang Cheng Dong Hui Ma Jing Wang Guangfa 
This work was supported bygrants from the National Natural Science Foundation of China (No. 30900646) and the National Science Foundation of China (No. 81241004). Conflict of interest: None.
Background Recent studies showed the central Na+/H+ exchanger type 3 (NHE3) has a close relationship with ventilation control.The objective of the study is to investigate the role of NHE3 in sleep apnea in Sprague...
关键词:Na+/H+ exchanger 3 RAT sleep apnea sleep monitoring 
Blockade of Na^+/H^+ exchanger type 3 causes intracellular acidification and hyperexcitability via inhibition of pH-sensitive K^+ channels in chemosensitive respiratory neurons of the dorsal vagal nucleus in rats被引量:1
《Neuroscience Bulletin》2014年第1期43-52,共10页Jing Zhang Hui Peng Sigrid C.Veasey Jing Ma Guang-Fa Wang Ke-Wei Wang 
supported by the National Natural Science Foundation of China(30900646 and 81241004)
Extracellular pH (pHe) and intracellular pH (pHi) are important factors for the excitability of chemosensitive central respiratory neurons that play an important role in respiration and obstructive sleep apnea. It...
关键词:Na^+/H^+ exchange potassium channel dorsal vagal nucleus in situ hybridization respiration 
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