国家自然科学基金(20042171)

作品数：3被引量：41H指数：3
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相关期刊：《Acta Pharmacologica Sinica》更多>>
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Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways被引量：16
《Acta Pharmacologica Sinica》2007年第12期1881-1890,共10页Ying JIN En-zhi YAN Ying FAN Xiao-li GUO Yan-jie ZHAO Zhi-hong ZONG Zhuo LIU 
This study was supported by a grant from the Natural Science Foundation of Liaoning Province(№ 20042171)
Aim： To investigate whether sodium ferulate （SF） can protect cortical neurons from glutamate-induced neurotoxicity and the mechanisms responsible for this protection. Methods： Cultured cortical neurons were incuba...
关键词：ferulic acid GLUTAMATE extracellular signal-regulated kinase phosphatidylinositol 3-kinase cortical neurons Bcl-2 μ-calpain 
Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus被引量：11
《Acta Pharmacologica Sinica》2006年第10期1309-1316,共8页Ying JIN Ying FAN En-zhi YAN Zhuo LIU Zhi-hong ZONG Zhi-min QI 
Project supported by Natural Science Foundation of Liaoning Province(No 20042171).
Aim： To observe the effects of sodium ferulate （SF） on amyloid beta （Aβ）1-40- induced p38 mitogen-activated protein kinase （MAPK） signal transduction pathway and the neuroprotective effects of SF. Methods： Ra...
关键词：ferulic acid amyloid MKK3/MKK6 p38mitogen-activated protein kinase INTERLEUKIN-1 27 kDa heat shock protein APOPTOSIS 
Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus被引量：18
《Acta Pharmacologica Sinica》2005年第8期943-951,共9页Ying JIN En-zhi YAN Ying FAN Zhi-hong ZONG Zhi-min QI Zhi LI 
Natural Science Foundation of Liaoning Province (№ 20042171)
Aim： To observe whether an amyloid β （Aβ）-induced increase in interleukin （IL）-1β was accompanied by an increase in the p38 mitogen-activated protein kinase（MAPK） pathway and a decrease in the cell survival ...
关键词：ferulic acid amyloid INTERLEUKIN-1 p38 mitogen-activated protein kinases extracellular signal-regulated kinases protooncogene proteins c-akt Alzheimer disease 
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