国家自然科学基金(31170868)

作品数：3被引量：2H指数：1
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The NLRP3 Inflammasome activation in human or mouse cells,sensitivity causes puzzle
《Protein & Cell》2013年第8期565-568,共4页Hongbin Wang Liming Mao Guangxun Meng 
This work was supported by grants from 100 Talent Program of the Chinese Academy of Sciences,National Natural Science Foundation of China(Grant Nos.91029707,31170868,812111134,and 31100622);SASIBS Scholarship Program,Chinese Post-doctoral Science Foundation(No.20110490752);Post-doctoral research foundation of Shanghai Institutes for Biological Sciences(No.2011KIP513);the National Science and Technology Key Project(No.2012ZX10002007-003);as well as the CAS/SAFEA International Partnership Program for Creative Research Teams.
SIGNAL 1 ALONE IS ENOUGH TO ACTIVATE THE NLRP3 INFLAMMAOSME IN HUMAN CELLS According to our current understanding,the NLR family,pyrin domain containing 3(NLRP3)infl ammasome activation is generally a two-step process...
关键词：NLRP3 ACTIVATION CYTOKINES 
Cellular localization of NLRP3 inflammasome被引量：2
《Protein & Cell》2013年第6期425-431,共7页Yan Wang Chen Yang Kairui Mao Shuzhen Chen Guangxun Meng Bing Sun 
the National Basic Research Program(973 Program)(No.2013CB530504);the National Natural Science Foundation of China(Grant Nos.31230024,31030029,31100662,91029707 and 31170868);the Shanghai Natural Science Foundation(No.11ZR1442600);the National Ministry of Sci-ence and Technology(No.2007DFC31700);the National Science and Technology Major Project(Nos.2008ZX10004-002,2008ZX10002-014,2009ZX10004-105,2009ZX10004-016,2011ZX10004-001 and 2012ZX10002007);the Shanghai Pasteur Health Research Foundation(SPHRF2008001 and SPHRF2009001);the Novo Nordisk-CAS Research Foundation,the SA-SIBS Discovery Innovation Grant,the Li Kha Shing Foundation,and the 100 Talent Program of the Chinese Academy of Sciences(to G.M.).
Infl ammasome is a large protein complex activated upon cellular stress or microbial infection,which triggers maturation of pro-inflammatory cytokines interleukin-1βand interleukin-18 through caspase-1 activation.Nod...
关键词：NLRP3 INFLAMMASOME ASC pyroptosome confocal microscopy CYTOPLASMIC 
Pannexin-1 infl uences peritoneal cavity cell population but is not involved in NLRP3 infl ammasome activation
《Protein & Cell》2013年第4期259-265,共7页Hongbin Wang Yue Xing Liming Mao Yi Luo Lishan Kang Guangxun Meng 
supported by grants from 100 Talent Program of the Chinese Academy of Sciences,National Natural Science Foundation of China(Grant Nos.91029707,31170868,812111134,and 31100622);Shanghai Natural Science foundation(11ZR1442600);Novo Nordisk-CAS Research Foundation(NN-CAS-2010-5(SIBS));SASIBS Scholarship Program,Chinese Post-doctoral Science Foundation(20110490752);Post-doctoral research foundation of Shanghai Institutes for Biological Sciences(2011KIP513);grants for excellent scientist from Ministry of Human Resources and Social Security of China.
Pannexin-1(Panx1)forms nonselective large channel in cell plasma membrane and has been shown to be associated with NLRP3 inflammasome activation,ATP release and phagocytes recruitment.In the current study,by manipulat...
关键词：innate Immunity INFLAMMASOME NLRP3 Pannexin-1 PERITONITIS 
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