supported by the funding from Total-IPS scientific partnership program,National Science and Technology Major Pro-jects of China(Nos.2008ZX10002-006 and 2012ZX10002007-001-080);The State Key Project on Infectious Diseases of China(No.2008ZX10002-018);Science Fund for Creative Research Groups,National Natural Science Foundation of China(Grant No.30921006).
The p53 signaling pathway works as a potent barrier to tumor progression.Two single nucleotide polymor-phisms(SNPs)in the gene loci of p53 pathway,p53 codon 72 Arg72Pro and MDM2 SNP309(T>G),have been shown to cause pe...
We thank Dr Claudia Cosentino and Dr Jin Q Cheng for kindly providing some of the plasmids. We are also grateful to Dr David Blake and Dr Xiaoni Kong (School of Public Health, Johns Hopkins University, Baltimore, MD) for helpful discussion. Research was supported by grants from the Funds for Creative Research Groups of China (30921006), the State Key Project for Liver Cancer (2008ZX10002), the State Key Laboratory of Oncogenes and Related Genes (91-10-02, 91-10-03), the National Natural Science Foundation of China (81001075, 81071778).
p28^GANK (also known as PSMD10 or gankyrin) is a novel oncoprotein that is highly expressed in hepatocellular carcinoma (HCC). Through its interaction with various proteins, p28^GANK mediates the degradation of th...