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国家自然科学基金(10175095): 作品数：34被引量：58H指数：5; 导出分析报告; 相关作者：孔福全梅俊平赵葵倪嵋楠隋丽更多>>; 相关机构：中国原子能科学研究院河北工业大学北京师范大学湖南农业大学更多>>; 相关期刊：《原子核物理评论》《原子能科学技术》《中国原子能科学研究院年报》《Annual Report of China Institute of Atomic Energy》更多>>; 相关主题：DNA损伤电离辐射重离子原子力显微镜INDUCED更多>>; 相关领域：生物学理学农业科学自动化与计算机技术更多>>

Theoretical Models of Cell Inactivation by Ionizing Particles: 《Annual Report of China Institute of Atomic Energy》2007年第1期92-93,共2页CAO Tian-guang MA Yun-zhi KONG Fu-quan YANG Ming-jian ZHUO Yi-zhong; National Natural Science Foundation of China (10647146, 10435020, 10175095); Ionizing radiation can induce various kinds of biological effects, its relative biological effectiveness (RBE) changes not only with the type of radiation and its energy, but also with the type of; 关键词：致电离粒子细胞失活理论模型相对生物效应致电离辐射

Monte-Carlo Simulation of Cellular S Value and Specific Energy for Electrons: 《Annual Report of China Institute of Atomic Energy》2007年第1期93-93,共1页GENG Jin-peng MA Yun-zhi CAO Tian-guang LI Yu-xiao ZHUO Yi-zhong; National Natural Science Foundation of China (10435020, 10175095); Various ionizing radiations transfer their energy to biological media by produced secondary electrons. In the diagnosis and therapy of nuclear medicine and BNCT, the radionuclides distribute; 关键词：蒙特卡洛模拟细胞失活生物效应致电离辐射比能

带电粒子致细胞失活的理论模型(英文)被引量：1: 《原子核物理评论》2007年第2期94-97,共4页曹天光马云志孔福全杨明建卓益忠; 国家自然基金重点资助项目(10647146 ,10435020 ,10175095)~~; 介绍了经辐射损伤后细胞失活或存活的理论模型及相关问题的一些研究工作。重点考虑了径迹结构和能量沉积特点的新的细胞失活模型。在径迹结构模拟的基础上,计算并分析了DNA损伤谱,同时把径迹结构得到的损伤谱与细胞存活联系起来,初步在...; 关键词：存活率 DNA损伤

Effect of Concentration of DNA in DNA Damage Induced by γ-ray: 《Annual Report of China Institute of Atomic Energy》2006年第1期104-104,共1页KONG Fu-quan ZHAO Kui WANG Xiao NI Mei-nan SUI Li YANG Ming-jian; National Natural Science Foundation of China (10175095,10435020);President Foundation of China Institute of Atomic Energy (12SZZ-200602); DNA is considered to be the most important bio-macromolecule and target molecule responsible for all biological effects. Many kinds of damage can be induced by radiation, such as base damage,; 关键词：DNA Γ射线相互作用物理效力

Effect of Dose Rate in DNA Damage Induced by γ-ray: 《Annual Report of China Institute of Atomic Energy》2006年第1期104-105,共2页KONG Fu-quan ZHAO Kui WANG Xiao NI Mei-nan SUI Li YANG Ming-jian; National Natural Science Foundation of China (10175095,10435020);President Foundation of China Institute of Atomic Energy (12SZZ-200602); DNA is considered to be the most important bio-macromolecule and target molecule responsible for all biological effects. Many kinds of damage can be induced by radiation, such as base damage,; 关键词：DNA Γ射线原子核原子能

辐射致DNA损伤及相关生物-化学-物理问题(英文): 《原子核物理评论》2005年第4期398-401,共4页曹天光蔡明辉耿金鹏孔福全马云志卓益忠; 国家自然科学基金资助项目(10175095)~~; 介绍了在DNA辐射损伤以及相关生物、物理、化学问题的一些研究工作。重点是径迹结构、DNA双链断裂和细胞学终点的关系。P53-Mdm2负反馈回路在DNA损伤的细胞响应方面起重要作用,用一个简单的模型研究了P53-Mdm2负反馈回路相互作用的动力...; 关键词：径迹结构存活率负反馈回路

Study on Double-Strand Break of DNA Irradiated by γ Rays: 《Annual Report of China Institute of Atomic Energy》2005年第1期90-91,共2页KONG Fu-quan, ZHAO Kui, SUI Li, CAI Ming-hui, YANG Ming-jian; Supported by National Natural Science Foundation of China (10175095,10435020) and President Foundation of China Institute of Atomic Energy; DNA is considered to be the most important bio-macromolecule and target molecule responsible for all biological effects. Many kinds of damage can be induced by radiation, such as base damage, single strand break（SSB...; 关键词：电离辐射 DNA损伤 Γ射线双键断裂重离子相对生物学效应

Study of DNA Sample for Atomic Force Microscopy: 《Annual Report of China Institute of Atomic Energy》2005年第1期88-89,共2页CAI Ming-hui ZHAO Kui ZHAN Yong NI Mei-nan SUI Li KONG Fu-quan YANG Ming-jian; Supported by National Natural Science Foundation of China (10175095, 10474018) and President Foundation of China Institute of Atomic Energy; Atomic Force Microscopy（AFM） was invented by Binnig, Calvin F.Quate and Christoph Gerber in 1986. AFM has unique advantages in observing biological sample. First of all, biological sample can be observed in physiolo...; 关键词：原子力显微镜法 DNA 显微图像结构

DNA End-Joining Catalyzed by Cell-Free Extracts After Damaged by Heavy Ions: 《Annual Report of China Institute of Atomic Energy》2005年第1期89-90,共2页KONG Fu-quan ZHAO Kui ZHOU Ping-kun NI Mei-nan SUI Li CAI Ming-hui; Supported by National Natural Science Foundation of China( 10175095, 10435020) and President Foundation of China Institute of Atomic Energy; It is ineluctability that the damage to astronaut will be induced by heavy ions along with the development to outer space. So the experiment of DNA end-joining catalyzed by cell-free extracts after DNA damaging by hea...; 关键词：重离子 DNA损伤体外修复末端连接实验

随机断裂模型对^(7)Li离子致DNA链断裂碎片长度分布的分析被引量：3: 《科学通报》2005年第10期947-951,共5页孔福全赵葵展永曹天光倪嵋楠隋丽蔡明辉卓益忠; 国家自然科学基金(批准号:10175095,10435020);中国原子能科学研究院院长基金资助项目.; 用随机断裂模型分析了重离子电离辐射致质粒DNA双链断裂(dsb)的片段长度分布,随机断裂模型中的u为平均每个DNA上的双链断裂数,并可直接由实验得到.分析表明在低剂量时,随机断裂模型都不能描述DNA的碎片分布.在较高剂量时,随机断裂模型...; 关键词：断裂模型长度分布 DNA链断裂碎片 DNA双链断裂电离辐射模型分析随机断裂统计性质重离子低剂量分析表高剂量大剂量实验质粒

国家自然科学基金(10175095)