Acknowledgements This work is partly supported by National Natural Science Foundation of China (81170040 and 81470229), and National Science and Technology Pillar Program during the Twelfth Five-year Period 2012BAI05B00. We are grateful for Prof Guan-liang SHAN's kind help in facilitating the whole experiment, and we thank the technicians at the Department of Pathology, Peking Union Medical College Hospital for help in generating the pathological slidesand the staff of the Animal Center, Peking Union Medical College Hospital for caring for the animals. We thank Dr Xi-qiang YAN for his generosity in providing recombinant IL-22 and his helpful comments.
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