《Chinese Chemical Letters》

作品数：15978被引量：15672H指数：20
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《Chinese Chemical Letters》
主办单位：Chinese Chemical Society;Institute of Materia Medica, Chinese Academy of Medical Sciences
最新期次：2025年3期更多>>
发文主题：NEWSYNTHESISNOVELDERIVATIVESN-更多>>
发文领域：理学化学工程医药卫生一般工业技术更多>>
发文作者：张洁王晓妮更多>>
发文机构：中国人民解放军更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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A“spore-like”oral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease
《Chinese Chemical Letters》2025年第3期389-395,共7页Junfei Yang Ke Wang Shuxin Sun Tianqi Pei Junxiu Li Xunwei Gong Cuixia Zheng Yun Zhang Qingling Song Lei Wang 
supported by the National Natural Science Foundation of China(Nos.82272847,82304417,82303529,82171333);China Postdoctoral Science Foundation(Nos.2023TQ0307,2023M743231,2023M730971);Science and Technology Project of Henan Province(No.242102311204);Postdoctoral Fellowship Program of CPSF(No.GZB20230675);Modern Analysis and Computer Center of Zhengzhou University.
Colon-targeted oral drug delivery systems are one of the most promising therapeutic strategies for alleviating and curing inflammatory bowel disease(IBD),but they still face challenges in successfully passing through ...
关键词：Gastrointestinal barrier Spore-like Precision targeted therapy Spore coat Gut microbiota 
Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy
《Chinese Chemical Letters》2025年第3期396-401,共6页Liqing Chen Zheming Zhang Yanhong Liu Chenfei Liu Congcong Xiao Liming Gong Mingji Jin Zhonggao Gao Wei Huang 
supported by CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-026,China).
Gliomas are the most common intracranial tumors with poor survival and high mortality.Furthermore,the clinical efficacy of current drugs is still not ideal;despite the development of several therapeutic drugs over the...
关键词：15-Amino-acid peptide GLIOMA Brain targeting Gene silencing Transvascular delivery 
Elaborate construction of pH-sensitive polymyxin B loaded nanoparticles for safe and effective treatment of carbapenem-resistant Klebsiella pneumoniae
《Chinese Chemical Letters》2025年第3期402-406,共5页Wen Zhong Dan Zheng Xukun Liao Yadi Zhou Yan Jiang Ting Gao Ming Li Chengli Yang 
supported by the National Natural Science Foundation of China(Nos.81860543,32360237);Guizhou Provincial Science and Technology Projects(Nos.ZK[2024]235,ZK[2023]Key Project 041).
The escalation in the incidence of multidrug-resistant Gram-negative bacteria is becoming a pressing global concern.Polymyxin B(PMB),a conventional antibiotic with notable therapeutic efficacy against Gram-negative ba...
关键词：Polymyxin B pH-sensitive modification Carbapenem-resistant Klebsiella pneumoniae ANTIBACTERIAL Biological security 
Chaeglobol A,an unusual octocyclic sterol with antifungal activity from the marine-derived fungus Chaetomium globosum HBU-45
《Chinese Chemical Letters》2025年第3期407-410,共4页Yun-Feng Liu Hui-Fang Du Ya-Hui Zhang Zhi-Qin Liu Xiao-Qian Qi Du-Qiang Luo Fei Cao 
funded by the S&T Program of Hebei(No.21323202D);the Natural Science Interdisciplinary Research Program of Hebei University(No.DXK201913);the Natural Sci-ence Foundation of Hebei Province of China(Nos.H2024201028,H2020201029);the Excellent Youth Research Innovation Team of Hebei University(No.QNTD202406);the Hebei University Research and Innovation Team(No.IT2023C1);the Innovation Capacity Improvement Plan of Hebei Province(No.20567605H);the National Training Program of Innovation and Entrepreneurship for Undergraduates(No.DC2024177)。
Chemical investigation of the marine-derived fungus Chaetomium globosum HBU-45 led to the discovery of chaeglobol A(1).Its structure was determined by spectroscopic analysis,computational electronic circular dichroism...
关键词：Marine-derived fungus Chaetomium globosum Octocyclic sterol Antifungal activity Single-crystal X-ray diffraction 
Hymoins A–C,three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum
《Chinese Chemical Letters》2025年第3期411-414,共4页Chunmao Yuan Yanrong Zeng Lei Huang Yu Mou Jun Jin Ping Yi Yanmei Li Xiaojiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035);the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...
关键词：Hypericum monogynum Polycyclic polyprenylated ACYLPHLOROGLUCINOLS Structure elucidation Lipid-lowering activity Mechanistic study 
Unveiling and swift diagnosing chronic wound healing with artificial intelligence assistance
《Chinese Chemical Letters》2025年第3期469-475,共7页Jiliang Deng Guoliang Shi Zhihang Ye Quan Xiao Xiaoting Zhang Lei Ren Fangyu Yang Miao Wang 
supported by the Fundamental Research Funds for the Central Universities(No.20720230037);the National Natural Science Foundation of China(No.52273305);Natural Science Foundation of Fujian Province of China(No.2023J05012);State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory(Nos.2023XAKJ0103071,2023XAKJ0102061);Natural Science Foundation of Xiamen,China(No.3502Z20227010).
Histopathological analysis of chronic wounds is crucial for clinicians to accurately assess wound healing progress and detect potential malignancy.However,traditional pathological tissue sections require specific stai...
关键词：Chronic wound Virtual pathological staining AI-assisted diagnostic and therapeutic Gel dressings 
Dual-defect engineering of catalytic cathode materials for advanced lithium-sulfur batteries
《Chinese Chemical Letters》2025年第3期476-482,共7页Na Li Wenxue Wang Peng Wang Zhanying Sun Xinlong Tian Xiaodong Shi 
financial support from National Natural Science Foundation of China(No.52101250);Hebei Provincial Natural Science Foundation(Nos.E2021208031 and B2021208069);S&T program of Hebei(Nos.215A4401D and 225A4404D);Research Fund of the Innovation Platform for Academicians of Hainan Province(No.YSPTZX202315);Collaborative Innovation Center of Marine Science and Technology of Hainan University(No.XTCX2022HYC14);partially supported by the Pico Election Microscopy Center of Hainan University;Fundamental Research Funds for the Hebei University(No.2021YWF11);Science Research Project of Hebei Education Department(No.QN2024087);Xingtai City Natural Science Foundation(No.2023ZZ027)
Sluggish conversion reaction kinetics and spontaneous shuttle effect of lithium polysulfides(LiPSs)are deemed as the two big mountains that hinder the practical application of lithium-sulfur batteries(LSBs).Herein,dua...
关键词：Dual-defect engineering Boron doping Phosphorus vacancy Catalytic cathode materials Lithium-sulfur batteries 
Rational design of highly conductive and stable 3D flexible composite current collector for high performance lithium-ion battery electrodes
《Chinese Chemical Letters》2025年第3期483-487,共5页Huanyan Liu Jiajun Long Hua Yu Shichao Zhang Wenbo Liu 
financially supported by the National Natural Science Foundation of China(Nos.52075351,51604177);the National Key Research and Development Program of China(No.2019YFA0705701);the National Funded Postdoctoral Researcher Program(No.GZC20231762);the Major S&T Infrastructure Construction Project of Sichuan Province(No.2020-510000-73-01441847);the International S&T Innovation Cooperation Program of Sichuan Province(No.2020YFH0039);the Chengdu International S&T Cooperation Funded Project(Nos.2020-GH02-00006HZ,2022-GH02-00027-HZ);the“1000 Talents Plan”of Sichuan Province,and the Talent Introduction Program of Sichuan University(No.YJ201410)。
Anode active materials involving transition metal oxides and sulfides are of great significance for high energy density lithium-ion batteries(LIBs),but the huge volume expansion and inferior electronic conductivity up...
关键词：Lithium-ion battery Composite current collector Highly conductive electrode High performance Metal sulfide 
Performance optimization of aqueous Zn/MnO^(2)batteries through the synergistic effect of PVP intercalation and GO coating
《Chinese Chemical Letters》2025年第3期488-493,共6页Shilong Li Ming Zhao Yefei Xu Zhanyi Liu Mian Li Qing Huang Xiang Wu 
supported by National Natural Science Foundation of China(No.52172218).
Manganese dioxide(MnO_(2))electrode material possesses the advantages of high energy density,structural diversity and high modification potential.This allows it become one of the important cathodes for aqueous zinc io...
关键词：Aqueous zinc ion batteries CATHODE MnO_(2) Cycle stability High capacity 
Facilitating the polysulfides conversion kinetics by porous LaOCl nanofibers towards long-cycling lithium-sulfur batteries
《Chinese Chemical Letters》2025年第3期494-499,共6页Tengfei Yang Jingshuai Xiao Xiao Sun Yan Song Chaozheng He 
supported by the Scientific Research Program Funded by Education Department of Shaanxi Provincial Government(No.22JK0411);the Natural Science Basic Research Program of Shaanxi Province(No.2023-JC-QN-0165);the National Natural Science Foundation of China(No.21603109).
Lithium-sulfur batteries are considered to be a new generation of high energy density batteries due to their non-toxicity,low cost and high theoretical specific capacity.However,the development of practical lithium-su...
关键词：Lithium-sulfur batteries POLYSULFIDES Shuttle effect LaOCl nanofibers High sulfur loading 
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