《Journal of Chinese Pharmaceutical Sciences》

作品数：2870被引量：3681H指数：16
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《Journal of Chinese Pharmaceutical Sciences》
主办单位：中国药学会
最新期次：2025年3期更多>>
发文主题：CHINESEPHARMACOKINETICSJOURNALDETERMINATIONHPLC更多>>
发文领域：医药卫生文化科学理学化学工程更多>>
发文作者：屠鹏飞张强崔景荣姜勇李润涛更多>>
发文机构：北京大学北京医科大学沈阳药科大学中国医学科学院北京协和医学院更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家科技支撑计划更多>>
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Study on chemical constituents from ethanol extract of Cyclocarya paliur
《Journal of Chinese Pharmaceutical Sciences》2025年第3期195-209,共15页Hailong Xu Jiao Yang Tianxia Wang Gaigai Deng Youbo Zhang 
The aim of this study is to isolate and identify the chemical compounds in ethanol extract of Cyclocarya paliurus.Some purification and analysis techniques like silica gel,D101-macroporous adsorptive resins,and Sephad...
关键词：Cyclocarya paliurus COMPONENTS Ethanol extract Ethyl acetate N-BUTANOL 
Synthesis and functional evaluation of low-molecular-weight dextran sulfate as an inhibitor of TGF-β1-induced epithelial-to-mesenchymal transition in A549 cells
《Journal of Chinese Pharmaceutical Sciences》2025年第3期210-222,共13页Guohao Song Linbo Fu Yidian Mo Tongtong Geng Ximin Lv Xiangbao Meng Heng Wang Zhongtang Li Zhongjun Li 
the National Natural Science Foundation of China(Grant Nos.92478133,81930097,and 82151223);by the State Key Laboratory of Natural and Biomimetic Drugs(Grant No.K202430).
Idiopathic pulmonary fibrosis(IPF)is a progressive and fatal interstitial lung disease characterized by excessive fibrotic remodeling,for which effective therapeutic options remain severely limited.Among the pathogeni...
关键词：Idiopathic pulmonary fibrosis Epithelial to mesenchymal transition Dextran sulfate sodium Transforming growth factor-β1 A549 
Analysis of 979 cases of adverse drug reactions induced by antineoplastic drugs
《Journal of Chinese Pharmaceutical Sciences》2025年第3期223-231,共9页Xingnong Xu Doudou He Lei Ma 
Collaborative Innovation Program of Jiangsu Pharmaceutical Vocational College(Grant No.20239120)。
The aim of this study is to evaluate the characteristics and patterns of adverse drug reactions(ADRs)associated with antineoplastic drugs and provide insights for safer chemotherapy practices.Based on 979 ADR cases re...
关键词：Anti-tumor drugs Adverse effects Drug safety 
Bibliometric analysis of PCSK9 inhibitors for cardiovascular disease management based on Web of Science
《Journal of Chinese Pharmaceutical Sciences》2025年第3期232-250,共19页Yu Wang Xiaojing Lu Xiangfeng Yue Linwei Kan Shuzhang Du 
supported by the National Natural Science Foundation of China(Grant No.81903685).
To comprehensively analyze the current research landscape and emerging trends in the application of pro-protein convertase subtilisin/kexin type 9(PCSK9)inhibitors for treating cardiovascular diseases,a bibliometric a...
关键词：PCSK9 inhibitors Cardiovascular diseases BIBLIOMETRICS VISUALIZATION VOSviewer CiteSpace 
Elucidating the mechanism of Kuwanon G in treating diabetic encephalopathy through network pharmacology:A comprehensive study
《Journal of Chinese Pharmaceutical Sciences》2025年第3期251-259,共9页Yuqian Zhang Haiying Niu Xiaowei Zhang Weiwei Xie Kaiyue Zhang Lantong Zhang Yiran Jin 
financially supported by the Hebei Administration of Traditional Chinese Medicine(Grant No.2024040)。
The present study employed network pharmacology to elucidate the molecular mechanism underlying the therapeutic effects of kuwanon G in diabetic encephalopathy.Utilizing the Pharmmapper databases,we identified potenti...
关键词：Kuwanon G Network pharmacology Diabetic encephalopathy MECHANISM 
Advancing pediatric drug development in China:implementation of the national priority R&D encouragement list
《Journal of Chinese Pharmaceutical Sciences》2025年第3期260-268,共9页Weimiao Li Jing Chen Luwen Shi 
supported by Noncommunicable Chronic Diseases-National Science and Technology Major Program(Grant No.2023ZD0509600);Researcher at the Chinese Academy of Sciences Think Tank on the Issues and Countermeasures in the Development of Innovative Drugs in China(Grant No.2023-ZY06-B-032).
Access to medicines for children is a critical global issue that demands urgent attention.In China,the need is particularly acute due to its large pediatric population and corresponding clinical demand.This study aime...
关键词：CHILDREN Policy implementation Investigational new drug New drug application Rare diseases 
Synthesis and in vitro/in vivo assessment of sustained-release oral oseltamivir phosphate suspension
《Journal of Chinese Pharmaceutical Sciences》2025年第3期269-283,共15页Yuanrong Xin Yutian Dou Xiaolin Chen Yingshu Feng Xuesheng Liu Caleb Kesse Firempong Dan Yang Hongfei Liu Haibing He 
2023 Nantong Jianghai Talents Project;2023 Nantong Social Livelihood Science and Technology Plan;2021 Jurong Social Development Science&Technology Program(Grant No.ZA42109);2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research Institute;China Postdoctoral Science Foundation(Grant No.2020M681532);Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.2020Z209);Natural Science Research Projects of Universities in Jiangsu Province(Grant No.20KJD350001)。
Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its com...
关键词：Oseltamivir phosphate SUSTAINED-RELEASE Ion exchange resin SUSPENSION 
Meta-analysis of the clinical efficacy of wax therapy combined with conventional pharmacotherapy in rheumatoid arthritis treatment
《Journal of Chinese Pharmaceutical Sciences》2025年第3期284-292,共9页Wangxing Zeng Qian Deng Zining Peng Fanyu Meng Weitian Yan Nian Liu Jiangyun Peng 
supported by the Key Research and Development Program of Yunnan Science and Technology Department(Grant No.202303AC100326);the National Natural Science Foundation of China(Grant No.81960863);the Education Department of Yunnan Province(Grant No.2023Y0463 and 2024Y380).
This study aimed to systematically evaluate the clinical efficacy of combining wax therapy with conventional drug therapy for rheumatoid arthritis(RA)and to provide evidence supporting its clinical application.A compr...
关键词：Rheumatoid arthritis Wax therapy Clinical effects META-ANALYSIS 
北京大学张力勤团队开发靶向蛋白质降解的核酸适体进化平台
《Journal of Chinese Pharmaceutical Sciences》2025年第3期293-298,共6页无 
靶向蛋白质降解(TPD)技术是近年来药物研发领域的前沿方向,通过利用细胞内的泛素-蛋白酶体系统来降解“不可成药”的蛋白质,为癌症等疾病的治疗提供了新的思路。然而,传统的TPD技术在开发过程中面临着靶向弹头和连接子优化的挑战。
关键词：靶向蛋白质降解 TPD技术 核酸适体进化平台 
周德敏团队在重组腺相关病毒载体开发领域取得新进展
《Journal of Chinese Pharmaceutical Sciences》2025年第3期299-299,共1页无 
近日,北京大学药学院周德敏团队基于非天然氨基酸和非天然糖策略,成功开发出新型重组腺相关病毒载体。这类载体能够根据需要靶向不同的受体和组织,为基因治疗提供了更高效的递送方案,成果发表在Journal of Controlled Release和Acta Bio...
关键词：重组腺相关病毒载体 非天然糖策略 非天然氨基酸 
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