DYSREGULATION

作品数：170被引量：528H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors
《Signal Transduction and Targeted Therapy》2022年第1期270-281,共12页Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei 
This study was supported by the joint emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology of China,Guangdong Science and Technology Department and Guangzhou Municipal Science and Technology Bureau(2020B111108001);Guangdong Science and Technology Department(2020B121206001&2020B1212030004);The funders had no role in study design,data collection and analysis,or preparation of the manuscript.
Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-relat...
关键词：metabolism mechanism resistance 
Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity被引量：10
《Cellular & Molecular Immunology》2018年第7期676-684,共9页Haijing Wu Yaxiong Deng Yu Feng Di Long Kongyang Ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu 
This work was supported by the National Natural Science Foundation of China(Nos.81220108017,81522038,81602767,81430074,91442116,81373195 and 81771761);National Basic Research Program of China(No.2014CB541904);the Programs of Science-Technology Commission of Hunan Province(2013F J4202);the Natural Science Foundation of Hunan Province(2017JJ3453);the Natural Key Clinical Speciality Construction Project of National Health and Family Planning Commission of the People’s Republic of China.
B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreig...
关键词：AUTOIMMUNITY B cell DNA methylation histone modification MICRORNA 
Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: Disease and treatments被引量：12
《World Journal of Gastroenterology》2014年第21期6448-6456,共9页Tung On Yau Ceen-Ming Tang Jun Yu 
Supported by Research Grants of National Basic Research Program of China (973 Program, 2010CB529305);Innovation and Technology Support Programme, Hong Kong (ITS/214/12)
Epstein-Barr virus(EBV)-associated gastric carcinoma(EBVaGC)comprises nearly 10%of gastric carcinoma cases worldwide.Recently,it was recognised to have unique clinicopathologic characteristics,including male predomina...
关键词：Epstein-Barr virus Gastric carcinoma Epigenetic dysregulation Aberrant DNA methylation Epigenetic therapies 
The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis被引量：3
《Genes & Diseases》2014年第1期106-112,共7页Yaxi Chen Zac Varghese Xiong Z.Ruan 
This study was supported by Major State Basic Research Development Program of China(973 Program,NO.2012CB517700&2012CB517500);the National Natural Science Foundation of China(81270493,81270789,81200567 and Key Program,No.81030008,81390354);the Moorhead Trust,the Royal Free Hospital Special Trustees Grant-115 through Dr.Zac Varghese,and Kidney Research UK(RP37/2008).
Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression ...
关键词：Ectopic lipid deposition Inflammation Lipid homeostasis Lipid redistribution Non-alcoholic fatty liver disease 
Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines被引量：5
《Chinese Medical Journal》2007年第24期2185-2190,共6页CHEN Ya-xi RUAN Xiong-zhong HUANG Ai-long LI Qiu John F. Moorhead Zac Varghese 
This study was supported by grants from the National Natural Science Foundation of China(Key Program,No.30530360);the National Basic Research Program of China(No.2006CB503907);Royal Free Hospital Special Trustees grant
Background Low-density lipoprotein （LDL） receptor is normally regulated via a feedback system that is dependent on intracellular cholesterol levels. We have demonstrated that cytokines disrupt cholesterol-mediated L...
关键词：low-density lipoprotein receptor CYTOKINES sterol regulatory element binding protein-2 SREBP cleavage-activating protein CHOLESTEROL 
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