SITE-SPECIFIC

作品数：120被引量：357H指数：8
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相关作者：程涵王勇博薛宇朱文远李新新更多>>
相关机构：华中科技大学北京大学广东省人民医院(广东省医学科学院)中国科学院更多>>
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Demethylase-assisted site-specific detection of N^(1)-methyladenosine in RNA
《Chinese Chemical Letters》2024年第5期397-401,共5页Jun Xiong Ke-Ke Chen Neng-Bin Xie Wei Chen Wen-Xuan Shao Tong-Tong Ji Si-Yu Yu Yu-Qi Feng Bi-Feng Yuan 
supported by the National Key R&D Program of China(Nos.2022YFC3400700 and 2022YFA0806600);the National Natural Science Foundation of China(Nos.22277093,22074110,21721005 and 22207090);the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(No.JCRCGW-2022-008);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(No.ZNJC202208)。
The dynamic RNA modifications have been viewed as new posttranscriptional regulator in modulating gene expression as well as in a broad range of physiological processes.N^(1)-methyladenosine(m^(1)A)is one of the most ...
关键词：N^(1)-methyladenosine RNA modification AlkB demethylase RNA epigenetics Quantitative real-time PCR Hepatocellular carcinoma 
Site-specific quantification of 5-carboxylcytosine in DNA by chemical conversion coupled with ligation-based PCR被引量：1
《Chinese Chemical Letters》2021年第11期3426-3430,共5页Qian Wang Jiang-Hui Ding Jun Xiong Yang Feng Bi-Feng Yuan Yu-Qi Feng 
supported by the National Natural Science Foundation of China(Nos.22074110,21635006,21721005);the Fundamental Research Funds for the Central Universities(2042021 kf0212).
5-Methylcytosine(5mC)is the most important epigenetic modification in mammals.The active DNA demethylation could be achieved through the ten-eleven translocation(TET)protein-mediated oxidization of 5mC with the genera...
关键词：5-Methylcytosine 5-Carboxylcytidine Dihydrouracil Mass spectrometry PCR Chemical conversion 
Site-specific protein modification by genetic encoded disulfide compatible thiols
《Chinese Chemical Letters》2020年第1期163-166,共4页Xinyu Ling Heqi Chen Wei Zheng Liying Chang Yong Wang Tao Liu 
financially supported by National Key Research and Development Program of China (No.2016YFA0201400);the National Natural Science Foundation of China (No.21778005);Peking University Health Science Center (Nos.BMU20160537 andBMU2017QQ006);the Youth Thousand-Talents Program of China for support
Cysteine chemistry provides a low cost and convenient way for site-specific protein modification.However,recombinant expression of disulfide bonding containing protein with unpaired cysteine is technically challenging...
关键词：Cysteine chemistry Genetic code expansion Protein modification Biorthogonal chemistry Disulfide bond 
Diphenyl cyclopropenone-centered polymers for site-specific CO-releasing and chain dissociation被引量：3
《Chinese Chemical Letters》2020年第1期299-302,共4页Chenchen Shao Hanyi Duan Yuqin Min Xinghong Zhang 
financial support by the National Science Foundation of China (No.21604071)
The synthesis and stimuli-responsiveness of a diphenyl cyclopropenone(DPCP)-centered poly(methyl acrylate)(PMA)are presented.DPCP-centered PMA could release carbon monoxide(CO)upon UV light in a switched on-and-off ma...
关键词：Diphenyl cyclopropenone CO-release Chain dissociation Ultrasound UV light 
Recent advances in enzyme-mediated peptide ligation被引量：6
《Chinese Chemical Letters》2018年第7期1009-1016,共8页Silin Xu Zhenguang Zhao Junfeng Zhao 
The National Natural Science Foundation of China (Nos. 21462023, 21778025);the Education Department of Jiangxi Province (No.150297)
Artificial synthesis and site-specific modification of peptides and proteins has evolved into an indispensable tool for protein engineers and chemical biologists. Chemical and enzymatic approaches to peptide ligation ...
关键词：LIGASE Peptide synthesis Protein engineering Enzyme-mediated peptide ligation Site-specific protein modification 
Site-specifically cleavage of oxidized insulin B chain with Zn(Ⅱ) ion studied by electrospray ionization mass spectrometry
《Chinese Chemical Letters》2007年第5期557-560,共4页Jiang Jiang Yu Hua Mei Long Gen Zhu Wen Ji Wang 
The electrospray ionization mass spectrometry and tandem mass spectrometry investigation showed that the binding sites of Zn^2＋ with oxidized insulin B chain are His 5, His 10, and Arg 22, which lead to the selective...
关键词：Oxidized insulin B chain ZNCL2 Mass spectrometry Hydrolytic cleavage 
Site-specifically Hydrolytic Cleavage of Oxidized Insulin B Chain With Cu(II) Ion
《Chinese Chemical Letters》2000年第11期951-954,共4页Xue Mei LUO Wei Jiang HE Yu ZHANG Zi Jian GUO Long Gen ZHU 
the National Natural Science Foundation of China (Grant Nos. 29871017 and 29823001).
Electrospray mass spectrometry investigation shows that denatured oxidized insulin B chain can be selectively cleaved by simple Cu(II) ion and the site of cleavage is at Gly8 - Ser9 bond which is second amide bond lef...
The Site-Specific Hydrolysis of l-β-Hydroxybaccatin Ⅱ by Aspergillus Niger被引量：2
《Chinese Chemical Letters》1996年第12期1091-1092,共2页Jun Zeng ZHANG Li He ZHANG(The National Research Laboratories of Natural and Biomimetic Drugs School of pharmaceutical Sciences, Beijing Medical Uaiversity, Beijing 100083)Di An SUN Jian Qiao GU Qi Cheng FANG(Institute of Materia MedicaChinese Academy 
The site-specific microbiological hydrolysis of a natural 1β-hydroxybaccatin I, with the culture of Aspergillus niger. is described.
关键词：SITE The Site-Specific Hydrolysis of l Hydroxybaccatin by Aspergillus Niger 
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