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Metabolic engineering of an industrial bacterium Zymomonas mobilis for anaerobic l-serine production: 《Synthetic and Systems Biotechnology》2024年第2期349-358,共10页Zhen Wang Xia Wang Xiongying Yan Haixia Yi Shuche He Haoyu Zhang Xinli Zhou Qiaoning He Shihui Yang; This work was supported by the National Key Research and Development Program of China(2022YFA0911800);National Natural Science Foundation of China(CN)(21978071);the Key Science and Technology Innovation Project of Hubei Province(2021BAD001);the Innovation Base for Introducing Talents of Discipline of Hubei Province(2019BJH021);We also acknowledge the support from the State Key Laboratory of Biocatalysis and Enzyme Engineering。; Due to the complicated metabolic and regulatory networks of l-serine biosynthesis and degradation,microbial cell factories for l-serine production using non-model microorganisms have not been reported.In this study,a ...; 关键词：Zymomonas mobilis Metabolic engineering L-SERINE Feedback inhibition Anaerobic fermentation

Efficient and selective removal of Pb(Ⅱ) from landfill leachate using L-serine-modified polyethylene/polypropylene nonwoven fabric synthesized via radiation grafting technique: 《Nuclear Science and Techniques》2024年第4期144-155,共12页Xin-Xin Feng Cheng Li Xuan-Zhi Mao Wan-Ning Ren Yang Gao Yu-Long He Zhe Xing Rong Li Guo-Zhong Wu; supported by the National Natural Science Foundation of China(Nos.11605275 and 11675247)。; In this study,to efficiently remove Pb(Ⅱ) from aqueous environments,a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent(NWF-serine)was fabricated through the radiation grafting of glycidyl me...; 关键词：Landfill leachate Radiation grafting Polyethylene/polypropylene nonwoven fabric Pb(Ⅱ)removal

Eubacterium rectale Improves the Efficacy of Anti-PD1 Immunotherapy in Melanoma via l-Serine-Mediated NK Cell Activation被引量：3: 《Research》2023年第4期777-792,共16页Nian Liu Lihui Chen Mingjie Yan Qian Tao Jie Wu Jing Chen Xiang Chen Wei Zhang Cong Peng; This work was supported by the National Key Research and Development Program of China(No.2021YFA1301200);the National Natural Science(grant No.82073458,82203024,8213000715,81830096,82073018,and 2022YFC2504700);the Science and Technology Innovation Program of Hunan Province(2021RC4013);the Program of Introducing Talents of Discipline to Universities(111 Project,no.B20017).; Natural killer(NK)cells,as key immune cells,play essential roles in tumor cell immune escape and immunotherapy.Accumulating evidence has demonstrated that the gut microbiota community affects the efficacy of anti-PD1 ...; 关键词：PD1 RECTAL MELANOMA

DL-Serine covalently modified multinuclear lanthanide-implanted arsenotungstates with fast photochromism被引量：1: 《Chinese Chemical Letters》2023年第2期572-575,共4页Kangting Zheng Bingxue Niu Cunmeng Lin Yizhen Song Pengtao Ma Jingping Wang Jingyang Niu; supported by the National Natural Science Foundation of China(No.222071043);the Major Project of Science and Technology,Education Department of Henan Province(No.20A150010);the 2021 Students Innovative Pilot Plan of Henan University(No.202110475079)。; A series of DL-serine covalently modified multinuclear lanthanide implanted arsenotungstates K_(2)[{Ln(H_(2)O)_(7)}_(2){As_(4)W_(44)O_(137)(OH)_(18)(H_(2)O)_(2)(DL-Ser)_(2)}{Ln_(2)(H_(2)O)_(5)(DL-Ser)}_(2)]·65H_(2)O(...; 关键词：Polyoxometalate ARSENOTUNGSTATE Carboxylate covalently modified LANTHANIDE PHOTOCHROMISM

Investigation of L/D-threonine substituted L-serine octamer ions by mass spectrometry and infrared photodissociation spectroscopy被引量：1: 《Chinese Chemical Letters》2017年第3期537-540,共4页Juan Ren Yi-Yun Wang Ru-Xia Fenga Xiang-Lei Kong; Financial support from the National Natural Science Foundation of China(No.21475065); Threonine-substituted serine octamer ions were generated by electrospray ionization（ESI） and investigated by mass spectrometry and infrared photodissociation（IRPD） spectroscopy. IRPD spectra of[L-Ser_7＋ L/D-Thr_1...; 关键词：IRPD spectroscopy Threonine Serine octamer Chiral differentiation Mass spectrometry

Synthesis,Crystal Structure and PTPs Inhibition of a Zinc(Ⅱ) Complex with N-(4-hydroxybenzyl)-L-serine: 《Chinese Journal of Structural Chemistry》2017年第2期316-323,共8页李艳红卢丽萍朱苗力袁彩霞冯思思高增强; Supported by NNSFC(Nos.21271121,21471092,21571118); The reaction of the reduced Schiff base HL（N-（4-hydroxybenzyl）-L-serine） with Zn（CH3COO）2·2H2O in aqueous solution afforded [Zn（L）2]·3H2O（I）. The complex has been characterized by elemental analysis, FT-IR...; 关键词：hydroxybenzyl Zinc Complex with N Synthesis carboxyl coordinated supramolecular distorted selectivity serine

A Copper(Ⅱ)Complex Based on N-(4-hydroxybenzyl)-L-serine:Synthesis,Crystal Structure and Inhibitory Activity on PTP1B and TCPTP被引量：2: 《Chinese Journal of Structural Chemistry》2016年第11期1686-1693,共8页李艳红卢丽萍朱苗力袁彩霞冯思思高增强; Supported by NNSFC(Nos.21271121,21471092,21571118); A novel copper（II） complex with the reduced Schiff base, [Cu（L）2]·H2O （I, HL = N-（4-hydroxybenzyl）-L-serine）, was prepared in aqueous solution and characterized by elemental analysis, FT-IR, electrospray ioni...; 关键词：copper（Ⅱ） complex N-（4-hydroxybenzyl）-L-serine crystal structure inhibitor PTP1B TCPTP

Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production被引量：15: 《Science China(Life Sciences)》2012年第4期283-290,共8页LAI ShuJuan ZHANG Yun LIU ShuWen LIANG Yong SHANG XiuLing CHAI Xin WEN TingYi; supported by grants from Ministry of Science and Technology of China (Grant Nos.2008ZX09401-05 and 2010ZX09401-403);the National Natural Science Foundation of China (Grant No. 31100074);Chinese Academy of Sciences (Grant No. XBXA-2011-009); L-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of L-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engine...; 关键词：Corynebacterium glutamicum L-SERINE intracellular metabolites metabolic engineering elementary mode analysis

L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices: 《Neuroscience & Medicine》2011年第3期268-274,共7页Kazutaka Shigemi Koji Tanaka Kohsuke Hayamizu Donald Michael Denbow Mitsuhiro Furuse; L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate ant...; 关键词：L-SERINE CHICK Brain SLICE TAURINE L-ALANINE

Efficacy of a novel endotoxin adsorber polyvinylidene fluoride fiber immobilized with L-serine ligand on septic pigs被引量：3: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2011年第4期264-272,共9页Jian-ping GAO Man HUANG Ning LI Peng-fei WANG Huan-lin CHEN Qiu-ping XU; Project (No.2007C33008) supported by the Key Scientific and Technological Project of Science and Technology Department of Zhejiang Province,China; A novel adsorber,polyvinylidene fluoride matrix immobilized with L-serine ligand (PVDF-Ser),was developed in the present study to evaluate its safety and therapeutic efficacy in septic pigs by extracorporeal hemoperfu...; 关键词：Sepsis ENDOTOXIN Adsorption Polyvinylidene fluoride matrix immobilized with L-serine ligand (PVDF-Ser) HEMOPERFUSION Pig

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