The current immunooncology artificially ignores the connection with lymphopoiesis, though is only its derivative. Hematopoietic stem cells (HSC) provide physiological regeneration of biomass of the host, fetus, and ma...
This work is supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA16010601);the CAS Key Research Program of Frontier Sciences(QYZDB-SSW-SMC057);the Major Research and Development Project of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110104006);the Chinese Ministry of Science and Technology(2015CB964401,2016YFA0100601,2017YFA0103401,2015CB964902,and 2015CB964901);the Health and Medical Care Collaborative Innovation Program of Guangzhou Scientific and Technology(201803040017);the Major Scientific and Technological Project of Guangdong Province(2014B020225005);the Science and Technology Planning Project of Guangdong Province(2017B030314056);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347);the National Natural Science Foundation of China(31471117,81470281,31600948,31425012).
Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs ...
B lymphocytes differentiate from hematopoietic stem cells through a series of distinct stages. Early B cell development proceeds in bone marrow until immature B cells migrate out to secondary lymphoid tissues, such as...
Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases.With the advances of genetic engineering and conditional knockout(CKO)mice,we now understand hematopo...