Figure 1.EGFR activation promotes TLR4 phosphorylation and cell surface expression of TLR4 in response to LPS.(A and B)BMDM were treated with LPS(1μg/mL)for 6,12,or 24 h in the presence or absence of pretreatment of ...
This work was supported by the National Institutes of Health Grant R01-HL-079669(J.F.and M.A.W.);National Institutes of Health Grant R01-HL-139547(J.F.and M.A.W.);National Institutes of Health Grant R01HL076179(P.W.and J.F.);VA Merit Award 1I01BX002729(J.F.);VA BLR&D Research Career Scientist Award BX004211(J.F.);National Natural Science Foundation of China 81671957(J.T.);Key projects of Guangdong Natural Science Foundation 2018B030311038(J.T.);Science and Technology Planning Project of Guangdong Province 2016A020215212(J.T.);National Institutes of Health Grant R01GM102146(M.J.S).
Dear Editor,oll-like receptor 4(TLR4)is a key receptor sensing bacterial lipopolysaccharide(LPS),and is the most investigated member of the Tol-like receptor family(Kawai and Akira,2007;Kayagaki et al,2013;Klein et al...