CASCADE

作品数：779被引量：1389H指数：14
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Mito-specific cascade amplifier sniping metabolism homeostasis for multimodal imaging-guided antitumor bioenergetic therapy
《Nano Research》2024年第11期9908-9919,共12页Jingjing Yang Yuanlin Zhang Maoquan Chu Jin Qian Jie Liu Manyu Wang Zhe Qiang Jie Ren 
financially supported by the Shanghai 2020 “Science and Technology Innovation Action Plan” Social Development Science and Technology Research Project(No.20dz1203600);the Fundamental Research Funds for the Central Universities,and the Open Funds for Characterization of Tongji University.
Nicotinamide adenine dinucleotide (NAD+/NADH) pools homeostasis is recognized as an Achilles’ Heel in tumor metabolism reprogramming. However, mitochondria can enable cancer cells to overcome NADH exhaustion by provi...
关键词：metabolism programming nicotinamide adenine dinucleotide(NAD+/NADH)pools homeostasis disruption mitochondrial-targeting cascade therapy magnetic resonance imaging(MRI)/photoacoustic imaging(PAI) 
Neutrophil-mimetic hybrid liposome with ROS cascade amplification for synergistic ferroptosis-photodynamic therapy of breast cancer
《Nano Research》2024年第11期9932-9941,共10页Jiaxin Li Jiaxin Li Jiao He Xuan He Dong Chen Ziyan Dong Lin Xiong Wenjing Bai Man Li Rong Guo Qin He 
supported by Sichuan Science and Technology program(No.2022NSFSC0045);Sichuan University Postdoctoral Research Foundation(No.2024SCU12130);National Postdoctoral Program(No.GZC20231780).
Photodynamic therapy (PDT) and ferroptosis therapy have received extensive attention in breast cancer treatment. PDT induced apoptosis of tumor cells by producing a large amount of reactive oxygen species (ROS) under ...
关键词：neutrophil-mimetic hybrid liposome reactive oxygen species(ROS)cascade amplification photodynamic therapy ferroptosis therapy breast cancer 
Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors
《Nano Research》2024年第4期2451-2461,共11页Zhichao Yu Ruijin Zeng Hexiang Gong Yuan Gao Shuyun Chen Yunsen Wang Dianping Tang 
supported by the National Natural Science Foundation of China(Nos.22274022,21874022 and 21675029).
Highly evolved multi-enzyme cascade catalytic reactions in organisms facilitate rapid transfer of substrates and efficient conversion of intermediates in the catalytic unit,thus rationalizing their efficient biocataly...
关键词：nanozyme single-atom catalyst BIOREACTOR cascade catalysis non-Invasive sensing 
Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy
《Nano Research》2023年第7期9642-9650,共9页Minchao Liu Hongyue Yu Liang Chen Tiancong Zhao Meng Fang Mengli Liu Qiaoyu Zhou Fatemah Farraj AlHarbi Ahmed Mohamed El-Toni Fan Zhang Dongyuan Zhao Xiaomin Li 
This work is supported by the National Natural Science Foundation of China(Nos.22075049,21875043,22088101,21701027,21733003,21905052,and 51961145403);the National Key R&D Program of China(Nos.2018YFA0209401 and 2018YFE0201701);Key Basic Research Program of Science and Technology Commission of Shanghai Municipality(No.17JC1400100);Natural Science Foundation of Shanghai(Nos.22ZR1478900,18ZR1404600,and 20490710600);Fundamental Research Funds for the Central Universities(20720220010);Shanghai Rising-Star Program(No.20QA1401200);The authors express their gratitude to Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2023R55);Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.The statements made herein are solely the responsibility of the authors。
Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment strategy.However,most of the reported cascade catalytic systems are designed based on symmetric-or co-assemb...
关键词：MESOPOROUS nanocatalytic medicine chemodynamic therapy asymmetric nanostructure core@shell 
Real-time in situ observation of P53-mediated cascade activation of apoptotic pathways with nucleic acid multicolor fluorescent probes based on symmetrical gold nanostars
《Nano Research》2023年第4期5391-5400,共10页Chenbiao Li Peifang Chen Xiaoyuan Ma Xichi Lin Shan Xu Sobia Niazi Zhouping Wang 
the financial support from the Jiangsu Agriculture Science and Technology Innovation Fund(No.CX(19)2005);the Social Development Fund Project of Wuxi(No.N20201001).
T-2 toxin,one of the most dangerous natural pollutants,induces apoptosis through multiple pathways.Amongst,P53 mediated apoptosis pathway,an important collection of molecules,plays a key role in cell vital activity.Re...
关键词：nucleic acid multicolor fluorescent probe symmetric gold nanostars T-2 toxin P53 mediated apoptosis pathway living cells imaging 
BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy被引量：1
《Nano Research》2022年第3期2235-2243,共9页Nan Yang Tian Zhang Changyu Cao Genxiang Mao Jinjun Shao Xuejiao Song Wenjun Wang Xiaozhou Mou Xiaochen Dong 
National Natural Science Foundation(NNSF)of China(Nos.61775095,61935004,and 51803091);Jiangsu Province Policy Guidance Plan(No.BZ2019014);Natural Science Foundation of Jiangsu Province(No.BK20200092);Natural Science Foundation of Shandong Province(No.ZR2020KB018);“Taishan scholars”construction special fund of Shandong Province.
Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence rate.Synergy therapy has been proven as a potent approach to minimize recurrence and achieve enhanced ...
关键词：chemotherapy chemodynamic therapy cascade therapy CDDP Fenton reaction 
Cerium oxide nanoparticles-mediated cascade catalytic chemo-photo tumor combination therapy
《Nano Research》2022年第1期333-345,共13页Zitao Hu Yin Ding 
supported by The National Key Research and Development Program of China(Nos.2018YFF0215500);National Natural Science Foundation of China(Nos.21105047,51773089,and 51973091);the Natural Science Foundation of Jiangsu Province(Nos.BK20181204 and BK20171258);the Science and Technology Items Fund of Nantong City(Applied Basic Research Programs 2017-N,No.MS12017027-2).
ROS-based tumor therapy based on nanocatalytic medicine has recently been proposed for its tumor-specificity.However,a safe and highly efficient strategy towards getting high enough ROS to kill the hypoxic cancer cell...
关键词：nanocatalytic medicine photodynamic therapy HYPOXIA cerium oxide@polyaniline combination therapy 
A photoactive process cascaded electrocatalysis for enhanced methanol oxidation over Pt-MXene-TiO2 composite被引量：5
《Nano Research》2020年第10期2683-2690,共8页Yue Sun Yunjie Zhou Yan Liu Qingyao Wu Mengmeng Zhu Hui Huang Yang Liu Mingwang Shao Zhenhui Kang 
National MCF Energy R&D Program(No.2018YFE0306105);Innovative Research Group Project of the National Natural Science Foundation of China(No.51821002);the National Natural Science Foundation of China(Nos.51725204,21771132,51972216,and 52041202);Natural Science Foundation of Jiangsu Province(Nos.BK20190041 and BK20190828);Key-Area Research and Development Program of GuangDong Province(No.2019B010933001);Collaborative Innovation Center of Suzhou Nano Science&Technology,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),and the 111 Project.
Highly efficient photo-assisted electrocatalysis for methanol oxidation reaction(MOR)realizes the conversion of solar and chemical energy into electric energy simultaneously.Here we report a Pt-MXene-TiO2 composite fo...
关键词：photoactive process ELECTROCATALYSIS CASCADE PHOTOELECTROCHEMISTRY methanol oxidation reaction 
Gold nanoparticles doped metal-organic frameworks as near-infrared light-enhanced cascade nanozyme against hypoxic tumors被引量：7
《Nano Research》2020年第3期653-660,共8页Xinli Liu Yongchun Pan Jingjing Yang Yanfeng Gao Ting Huang Xiaowei Luan Yuzhen Wang Yujun Song 
This work was financially supported by the National Natural Science Foundation of China(Nos.21874066,81601632 and 61804076);the Natural Science Foundation of Jiangsu Province(Nos.BK20160616 and BK20180700);the Fundamental Research Funds for Central Universities,the Shuangchuang Program of Jiangsu Province,and the Thousand Talents Program for Young Researchers.
We report gold nanoparticles(AuNPs)doped iron-based metal-organic frameworks(GIM)which displays near-infrared light(NIR)-enhanced cascade nanozyme against hypoxic tumors.Due to the strong protein adsorption-induced su...
关键词：nanozyme metal-organic frameworks gold nanoparticles near-infrared light reactive oxygen species 
Design and roles of RGO-wrapping in charge transfer and surface passivation in photoelectrochemical enhancement of cascade-band photoanode
《Nano Research》2017年第7期2415-2430,共16页Zhuo Zhang Mingi Choi Minki Baek Insung Hwang Changshin Cho Zexiang Deng Jinwoo Lee Kijung Yong 
Fast charge transfer and anti-photocorrosion are two crucial factors for developing efficient, durable photoanodes for photoelectrochemical （PEC） cells. Reduced graphene oxide （RGO） is a promising photoanode eleme...
关键词：PHOTOELECTROCHEMICAL reduced graphene oxide（RGO） charge transfer surface passivation CDSE ZnO 
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