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Multiplexed single-molecule force spectroscopy for dissecting biophysical regulation of membrane receptors functions on live cells
《Biophysics Reports》2021年第5期377-383,共7页Chenyi An Wei Chen 
This work was supported by grants from the National Basic Research Program of China(2015CB910800 and 2017ZX10203205);the National Science Foundation of China(31522021 and 31971237);the Fundamental Research Funds for the Central Universities(2015XZZX004-32);China Postdoctoral Science Foundation(2020M681834)。
Complex physical cues including two-dimensional membrane environment,dynamic mechanical force,and bioelectric activity inevitably affect membrane receptor functions.Multiplexed single-molecule force spectroscopy(SMFS)...
关键词：Multiplexed SMFS techniques Membrane receptor Biophysical regulation Live cell 
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution被引量：3
《Cell Research》2021年第4期463-477,共15页Li Li Lin Li Qingqing Li Xixi Liu Xinyi Ma Jun Yong Shuai Gao Xinglong Wu Yuan Wei Xiaoye Wang Wei Wang Rong Li Jie Yan Xiaohui Zhu Lu Wen Jie Qiao Liying Yan Fuchou Tang 
The study was supported by the Beijing Advanced Innovation Center for Genomics at Peking University;We sincerely thank Fei Wang and Xuefang Zhang from the National Center for Protein Sciences Beijing(Peking University)for assisting with the FACS analysis;Part of the bioinformatic analyses were run on the Computing Platform of the Center for Life Science;The study was supported by the Beijing Municipal Science and Technology Commission(Z181100001318001);the National Natural Science Foundation of China(31625018,31890781,81521002 and 81730038);the National Basic Research Program of China(2018YFA0107601,2018YFC1004000 and 2017YFA0102702).
Proper development of fetal germ cells(FGCs)is vital for the precise transmission of genetic and epigenetic information through generations.The transcriptional landscapes of human FGC development have been revealed;ho...
关键词：FETAL PRECISE LANDSCAPE 
Bin-based model construction and analytical strategies for dissecting complex traits with chromosome segment substitution lines被引量：1
《Chinese Science Bulletin》2012年第21期2666-2674,共9页TANG ZaiXiang XIAO Jing HU WenMing YU Bo XU ChenWu 
supported by the National Basic Research Program of China(2011CB100106);the National Natural Science Foundation of China(30971846and31171187);the Vital Project of Natural Science of Universities in Jiangsu Province(09KJA210002) to C.Xu;the National Natural Science Foundation of China(31100882) to Z.Tang;National Natural Science Foundation of China(31000539) to J.Xiao
Chromosome segment substitution lines have been created in several experimental models,including many plant and animal species,and are useful tools for the genetic analysis and mapping of complex traits.The traditiona...
关键词：染色体片段置换系 数量性状位点 基于模型 解剖 上位性效应 QTL分析 线性模型 变量选择 
A new approach to dissecting complex traits by combining quantitative trait transcript (QTT) mapping and diallel cross analysis被引量：3
《Chinese Science Bulletin》2012年第21期2695-2700,共6页YANG DaiGang YE ChengYin MA XiongFeng ZHU ZhiHong ZHOU XiaoJian WANG HaiFeng MENG QingQin PEI XiaoYu YU ShuXun ZHU Jun 
supported by the National Basic Research Program of China(2011CB109306);the National High Technology Research and Development Program of China(2009ZX08009-004B,2011AA10A102);the CNTC(110200701023);the YNTC(08A05);the earmearked fund for Modern Agro-industry Technology Reasearch System(CARS-18-05)
A promising way to uncover the genetic architectures underlying complex traits may lie in the ability to recognize the genetic variants and expression transcripts that are responsible for the traits' inheritance.Howev...
关键词：双列杂交分析 数量性状 成绩 差异表达基因 映射 解剖 混合线性模型 遗传变异 
Dissecting anxiety-related QTLs in mice by univariate and multivariate mapping被引量：2
《Chinese Science Bulletin》2012年第21期2727-2732,共6页ZHU ZhiHong ZHANG ChenHao WANG XuSheng COOK Melloni N WILLIAMS Robert LU Lu ZHU Jun 
supported by National Basic Research Program of China(2011CB109306);National Key Technologies R&D Program in China(2009ZX08009-004B);CNTC(110200701023);YNTC(08A05)
To detect genes underlying anxiety-related traits in mice,we performed univariate and multivariate QTL mapping analyses of phenotypes obtained from 71 mice of the BXD recombinant inbred (RI) strains (n=528 mice) and t...
关键词：QTL定位 映射分析 焦虑 小鼠 多变量 单变量 QTL效应 解剖 
Dissecting the Genetic Basis of Extremely Large Grain Shape in Rice Cultivar 'JZ1560'被引量：11
《Journal of Genetics and Genomics》2012年第7期325-333,共9页Jie-Zheng Ying Ji-Ping Gao Jun-Xiang Shan Mei-Zhen Zhu Min Shi Hong-Xuan Lin 
supported by grants from the Ministry of Agriculture of China(2009ZX08009-102B);Chinese Academy of Sciences(KSCX3-EW-N-01);the Ministry of Science and Technology of China(2012CB944800);the National Natural Science Foundation of China(31130071);the Zhejiang Provincial Natural Science Foundation of China (Y3110394)
Rice grain shape, grain length （GL）, width （GW）, thickness （GT） and length-to-width ratio （LWR）, are usually controlled by multiple quantitative trait locus （QTL）. To elucidate the genetic basis of extremely...
关键词：RICE Quantitative trait locus Additive effect Grain shape 
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