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Dissecting Spatiotemporal Structures in Spatial Transcriptomics via Diffusion-Based Adversarial Learning
《Research》2025年第1期292-307,共16页Haiyun Wang Jianping Zhao Qing Nie Chunhou Zheng Xiaoqiang Sun 
supported by grants from the National Key R&D Program of China(2021YFF1200903);the National Natural Science Foundation of China(62273364,11931019,11871070,and 62362062);the Guangdong Basic and Applied Basic Research Foundation(2020B1515020047);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(231lgbj025);the open fund of Information Materials and Intelligent Sensing Laboratory of Anhui Province(grant no.IMIS202105).
Recent advancements in spatial transcriptomics(ST)technologies offer unprecedented opportunities to unveil the spatial heterogeneity of gene expression and cell states within tissues.Despite these capabilities of the ...
关键词：adversarial graph autoencoder spatial transcriptomics st technologies cell states spatiotemporal structures computational frameworkpearlst partial gene expression spatial transcriptomics accurate infe 
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing
《Science China(Life Sciences)》2025年第1期116-129,共14页Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang 
supported from Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2023D003,CI2021B014);the National Key Research and Development Program of China(2022YFC2303600,2020YFA0908000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202002);the CACMS Innovation Fund(CI2023E002,CI2021A05101,CI2021A05104);the Science and Technology Foundation o f Shenzhen(JCYJ20210324115800001);the Science and Technology Foundation of Shenzhen(Shenzhen Clinical Medical Research Center for Geriatric Diseases);the Shenzhen Medical Research Fund(B2302051);the National Natural Science Foundation of China(82201786);Guangdong Basic and Applied Basic Research Foundation(2021A1515110646);Guangdong-Dongguan Joint Fund Regional Cultivation Project(2021B1515140033);Dongguan Science and Technology of Social Development Program(20211800904742,20221800905732,20221800904462).
Ovarian endometrioma(OE),also known as“chocolate cysts,”is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue ou...
关键词：OVARY high-throughput sequencing TRANSCRIPTOMICS gene expression analysis ligand-receptor analysis 
Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
《Protein & Cell》2024年第12期889-905,共17页Mengxue Zeng Kun Wang Qingcui Wu Jingjin Ding Dan Xie Xiangbing Qi Feng Shao 
supported by the National Key R&D Program of China(2022YFA1304700);the CAS Strategic Priority Research Program(XDB37030202);the Basic Science Center Project(82388201)of NSFC;the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-084);F.S.is also supported by the Tencent New Cornerstone Investigator Program.
Caspase-2,a highly conserved member of the caspase family,is considered an initiator caspase that triggers apoptosis in response to some cellular stresses.Previous studies suggest that an intracellular multi-protein c...
关键词：caspase-2 PIDDosome BID apoptosis chemical screen AGONIST 
Dissecting Superradiant Phase Transition in the Quantum Rabi Model
《Chinese Physics Letters》2024年第12期30-34,共5页Yun-Tong Yang Hong-Gang Luo 
National Key Research and Development Program of China(Grant No.2022YFA1402704);National Natural Science Foundation of China(Grant No.12247101).
Phase transitions are both thermodynamically and quantum-mechanically ubiquitous in nature and laboratories,and their understanding remains one of the most active issues in modern physics and related disciplines.The L...
关键词：TRANSITIONS mechanism PHASE 
A Case Report of Intramyocardial Dissecting Hematoma Similar to Left Ventricular Mural Thrombus
《Yangtze Medicine》2024年第4期83-89,共7页Ruirui Yue Yudong Peng Wei Xu 
Background: Intramyocardial Dissecting Hematoma (IDH) is one of the serious and rare complications of acute myocardial infarction (AMI). It is a manifestation of subacute cardiac rupture and has a high mortality rate....
关键词：Myocardial Infarction Intramyocardial Dissecting Hematoma ECHOCARDIOGRAPHY Left Ventricular Opacification 
Genome-wide association study dissecting drought resistance-associated loci based on physiological traits in common bean
《Journal of Integrative Agriculture》2024年第11期3657-3671,共15页Lei Wu Yujie Chang Lanfen Wang Shumin Wang Jing Wu 
supported by the National Key Research and Development Program of China(2019YFD1001300 and 2019YFD1001305);the Fundamental Research Funds for the Central Universities,China(SWUKQ22042);the China Agriculture Research System of MOF and MARA(CARS-08);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences。
Genetic improvement of drought resistance is one of the main breeding goals for common bean,so molecular markers must be identified to facilitate drought resistance breeding.In this study,we evaluated the proline,treh...
关键词：common bean drought resistance GWAS physiological trait 
Dissecting Combinational Mechanisms of Herbal Formula from a Transcriptome-based Multi-scale Network Pharmacology Model
《World Journal of Traditional Chinese Medicine》2024年第3期383-398,共16页Peng Li Tong Jin Qing-Qiong Deng Ning Chen Hao-Ran Zhang Wu-Xia Zhang Yi-Jie Li Zi-Yu Meng Lin Xing Yuan-Yuan Zhang Ling-Min Zhan Cai-Ping Cheng Jin-Zhong Zhao Bang-Ze Fu Tian-Gang Li Peng Lu 
supported by the National Natural Science Foundation of China (Nos.82274363, 31800678 and 82174224);the Science and Technology Innovation Project of Colleges and Universities in Shanxi Province (Nos.2019L0360 and 2021L146);the Key Research Program of the Chinese Academy of Sciences (No. ZDRW-ZS-2021.1-2)
Objective: Illumination of the integrative effects of herbs in a formula is a bottleneck that limits the development of traditional Chinese medicine(TCM). In the present study, we developed a transcriptome-based multi...
关键词：Combinational mechanisms herbal formula multi‑scale traditional Chinese medicine TRANSCRIPTOME 
Comparison of Partial Upper Sternotomy Versus Median Sternotomy for Total Arch Replacement in Patients With Type A Aortic Dissection
《Cardiology Discovery》2024年第3期192-199,共8页Dong Li Lei Chen Yang Wu Wei Jiang Chonglei Ren Cangsong Xiao 
Objective:Comparative studies of median sternotomy and partial upper sternotomy in total arch replacement for type A aortic dissection are rare,and the safety and benefits of partial upper sternotomy need further eval...
关键词：Aneurysm dissecting Acute type A aortic dissection Total arch replacement Partial upper sternotomy Median sternotomy 
Does MgSO_(4) protect the preterm brain?Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy
《Neural Regeneration Research》2024年第9期1861-1862,共2页Robert Galinsky Laura Bennet Alistair J.Gunn 
This work was supported by Health Research Council of New Zealand(grants 17/601 and 22/559);the Auckland Medical Research Foundation,the Lottery Health Grants Board of New Zealand,the C.J.Martin Postdoctoral Fellowship and project grant from the National Health and Medical Research Council of Australia(APP1090890 and APP1164954);the Victorian Government’s Operational Infrastructure Support Program(to RG).
Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal medicine.Preterm encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts ...
关键词：ENCEPHALOPATHY mortality HYPOXIC 
Dissecting Causal Relationships Between Plasma Metabolites and Osteoporosis:A Bidirectional Mendelian Randomization Study
《Chinese Medical Sciences Journal》2024年第3期185-192,共8页Hao Lv Ge Zhang Zhi-Mu Hu Qing-Song Chu Jiu-Xiang Wang Ting Jiang 
安徽省自然科学基金项目(2308085MH294);安徽省高校自然科学研究项目(2022AH050510);安徽省重点研发项目(202104j07020010);安徽中医药大学自然科学基金项目(2020yfyzc27)。
Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR) analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wid...
关键词：OSTEOPOROSIS plasma metabolites mendelian randomization bidirectional analysis 
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