AGONISTS

作品数：136被引量：373H指数：10
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相关机构：北京大学中国医科大学中国科学院北京中医药大学更多>>
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Design, Synthesis and Biological Evaluation of Potent and Selective S1PR1 Agonists for the Treatment of Ulcerative Colitis被引量：1
《Chinese Journal of Chemistry》2022年第22期2625-2632,共8页Huan He Mengting Xie Mengting Zhang Haiqin Zhang Huan Zhu Yuxian Fang Zihao Shen Rui Wang Zhenjiang Zhao Lili Zhu Xuhong Qian Honglin Li 
supported in part by the National Natural Science Foundation of China(grants 81825020 and 82150208 to H.L.);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project(grants 21S11907900 and 20S11901000 to Z.Z.);the Fundamental Research Funds for the Central Universities.Honglin Li is also sponsored by National Program for Special Supports of Eminent Professionals and National Program for Support of Top-notch Young Professionals.
The binding of Sphingosine-1-phosphate(S1P)with the S1PR1-5 plays a fundamental physiological role in a number of processes including vascular development and stabilization,lymphocyte migration and distribution.S1P-S1...
关键词：Ulcerativecolitis S1PR1 INFLAMMATION Drugdesign Structure-activity relationships 
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists
《Chinese Chemical Letters》2016年第1期159-162,共4页Jing Huang Bin Guo Wen-Jing Chu Xin Xie Yu-She Yang Xian-Li Zhou 
supported by grants from the National Natural Science Foundation of China (No. 2140222)
GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety pro...
关键词：GPR40 ANTI-DIABETIC Agonist Phenylpropionic acid derivative 
Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy被引量：3
《Acta Pharmacologica Sinica》2014年第11期1463-1472,共10页Xiao-yin WANG Shu-yong ZHANG Jing LI Hua-nan LIU Xin XIE Fa-jun NAN 
Acknowledgements This work was supported by grants from the National Science and Technology Major Projects for Major New Drugs Innovation and Development （No 2012ZX09304011, 2013ZX09507001, and 2012ZX09301001-005）, National Basic Research Program of China （973 Program） （No 2014CB541906） and the National Natural Science Foundation of China （No 30725049 and 81202341）,
Aim： TGR5 is a G protein-coupled receptor that is expressed in intestinal L-cells and stimulates glucagon-like peptide 1（GLP-1） secretion. TGR5 may represent a novel target for the treatment of metabolic disorder. ...
关键词：TGR5 ACTIVATOR betulinic acid derivatives GLP-1 LIPOPHILIC structure modifications 
The first examples of ilexgenin A hybrids as a new class of multi-potent,anti-platelet agents被引量：2
《Chinese Chemical Letters》2013年第8期723-726,共4页Li-Ping Lin Fei-Hua Wu Jing-Yu Liang 
supported by a grant from the Postgraduate Innovation Project of Jiangsu Province,China(No. CX09B_284Z);the Natural Science Foundation of Jiangsu Province,China(No.BK2012378)
Seventeen novel ilexgenin A hybrids（lA-aspirin） and（IA-NO）,as donor hybrids（IA-NO will release NO in vivo and function as NO donor）,were designed and synthesized in order to develop new multi-targeting agents fo...
关键词：Ilexgenin A Hybrids Multi-potent anti-platelet activity ADP agonists 
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