GLYCOSYLATED

作品数：37被引量：79H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：黄刚良更多>>
相关机构：北京大学中国农业科学院重庆师范大学更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Diabetes》《Chemical Research in Chinese Universities》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关基金：国家自然科学基金上海市自然科学基金高等学校学科创新引智计划中国博士后科学基金更多>>
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Targeted protein editing technique in living mammalian cells by peptide-fused PNGase
《hLife》2024年第11期576-591,共16页Min Wu Guijie Bai Ziyi Zhang Haixia Xiao Wenliang Sun Chaoguang Tian 
supported by funding from the Key Project of the Ministry of Science and Technology of China(2018YFA0900500).
Various precise gene editing techniques at the DNA/RNA level,driven by clustered regularly interspaced short palindrome repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology,have gained significant prominence.Ye...
关键词：N-glycosylated proteins peptide:N-glycanase(PNGase) protein-targeting peptides DEGLYCOSYLATION protein sequence editing protein degradation 
Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration
《Bioactive Materials》2024年第8期169-180,共12页Yuanman Yu Rui Chen Xinye Chen Jing Wang Changsheng Liu 
supported by the Basic Science Center Program of National Natural Science Foundation of China(No.T2288102);the Key Program of the National Natural Science Foundation of China(No.32230059);the National Natural Science Foundation of China(No.32101086);the National Postdoctoral Program for Innovative Talents(BX2021101);the China Postdoctoral Science Foundation Funded Project(2021M701192);Fundamental Research Funds for the Central Universities(JKD01221507);the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry(JKVD1211002).
Recombinant human bone morphogenetic protein-2(rhBMP-2)is the predominant growth factor that effectively induces osteogenic differentiation in orthopedic procedures.However,the bioactivity and stability of rhBMP-2 are...
关键词：Recombinant human bone morphogenetic protein-2 Osteogenic activity Protein stability Sulfated polysaccharide 
N-Glycosylated type Ⅱ collagen peptides as therapeutic saccharide vaccines for rheumatoid arthritis被引量：1
《Chinese Chemical Letters》2024年第5期197-200,共4页Dake Liu Shuyan Liu Fanlei Hu Zhongtang Li Zhongjun Li 
supported by the National Natural Science Foundation of China(Nos.81930097,21977005,82151223);supported by the National Key R&D Program of China(No.2022YFF1203005).
The interaction among type Ⅱ collagen(CⅡ),human DR4 major histocompatibility complex type Ⅱ molecule(MHC Ⅱ)and T-cell receptor(TCR)is associated with the development of rheumatoid arthritis(RA).The activation of T...
关键词：Rheumatoid arthritis TypeⅡcollegan GLYCOSYLATION N-Glycosylated altered peptides Saccharide vaccines 
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