GLYCOSYLATED

作品数：37被引量：79H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：黄刚良更多>>
相关机构：北京大学中国农业科学院重庆师范大学更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Diabetes》《Chemical Research in Chinese Universities》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关基金：国家自然科学基金上海市自然科学基金高等学校学科创新引智计划中国博士后科学基金更多>>
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Targeted protein editing technique in living mammalian cells by peptide-fused PNGase
《hLife》2024年第11期576-591,共16页Min Wu Guijie Bai Ziyi Zhang Haixia Xiao Wenliang Sun Chaoguang Tian 
supported by funding from the Key Project of the Ministry of Science and Technology of China(2018YFA0900500).
Various precise gene editing techniques at the DNA/RNA level,driven by clustered regularly interspaced short palindrome repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology,have gained significant prominence.Ye...
关键词：N-glycosylated proteins peptide:N-glycanase(PNGase) protein-targeting peptides DEGLYCOSYLATION protein sequence editing protein degradation 
Preparation,characterization and antioxidant activity analysis of three Maillard glycosylated bone collagen hydrolysates from chicken,porcine and bovine
《Food Science and Human Wellness》2024年第4期2002-2013,共12页Liwei Qi Hongru Zhang Yujie Guo Hong Liu Chunhui Zhang 
supported by the National Natural Science Foundation of China(32101883);Fellowship China Postdoctoral Science Foundation(2021M693902);National Agricultural Science and Technology Innovation Project(CAAS-ASTIP-2022)。
Bone collagen hydrolysates(peptides)derived from byproduct of animal product processing have been used to produce commercially valuable products due to their potential antioxidant activity.Maillard glycosylated reacti...
关键词：Bone collagen hydrolysates Glycosylation reaction Antioxidant activity 
Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration
《Bioactive Materials》2024年第8期169-180,共12页Yuanman Yu Rui Chen Xinye Chen Jing Wang Changsheng Liu 
supported by the Basic Science Center Program of National Natural Science Foundation of China(No.T2288102);the Key Program of the National Natural Science Foundation of China(No.32230059);the National Natural Science Foundation of China(No.32101086);the National Postdoctoral Program for Innovative Talents(BX2021101);the China Postdoctoral Science Foundation Funded Project(2021M701192);Fundamental Research Funds for the Central Universities(JKD01221507);the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry(JKVD1211002).
Recombinant human bone morphogenetic protein-2(rhBMP-2)is the predominant growth factor that effectively induces osteogenic differentiation in orthopedic procedures.However,the bioactivity and stability of rhBMP-2 are...
关键词：Recombinant human bone morphogenetic protein-2 Osteogenic activity Protein stability Sulfated polysaccharide 
N-Glycosylated type Ⅱ collagen peptides as therapeutic saccharide vaccines for rheumatoid arthritis被引量：1
《Chinese Chemical Letters》2024年第5期197-200,共4页Dake Liu Shuyan Liu Fanlei Hu Zhongtang Li Zhongjun Li 
supported by the National Natural Science Foundation of China(Nos.81930097,21977005,82151223);supported by the National Key R&D Program of China(No.2022YFF1203005).
The interaction among type Ⅱ collagen(CⅡ),human DR4 major histocompatibility complex type Ⅱ molecule(MHC Ⅱ)and T-cell receptor(TCR)is associated with the development of rheumatoid arthritis(RA).The activation of T...
关键词：Rheumatoid arthritis TypeⅡcollegan GLYCOSYLATION N-Glycosylated altered peptides Saccharide vaccines 
The role of N-glycosylation in cancer被引量：4
《Acta Pharmaceutica Sinica B》2024年第3期1098-1110,共13页Yu Lin David M.Lubman 
support of this work from the National Cancer Institute under Grants 1R01 CA160254 and U01 CA225753(David M.Lubman,USA)。
Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer glycoproteome.Glycoproteins play an important role in me...
关键词：N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers 
Synthesis and immunological study of a glycosylated wall teichoic acid-based vaccine against Staphylococcus aureus
《Chinese Chemical Letters》2023年第4期193-197,共5页Peng Shen Han Lin Yikai Bao Haofei Hong Zhimeng Wu 
supported by the National Natural Science Foundation of China (Nos. 21472070 and 22177040);partly supported by the 111 Project (No. 111-2-06)。
Staphylococcus aureus wall teichoic acids(WTAs) are attractive targets for antibacterial vaccine development. In this study, three core glycosylated WTA structure, including α-1,4-Glc NAc, β-1,4-Glc NAc andβ-1,3-Gl...
关键词：WTAs Staphylococcus aureus GlcNAc modifications GLYCOCONJUGATES Antibacterial vaccine 
Effects of the seasonal variation in the phytochemical composition and bioactivities of the wild halophyte Suaeda fruticosa
《Food Bioscience》2022年第6期1805-1811,共7页Mariem Maatallah Zaier Sandrina A.Heleno Filipa Mandim Ricardo C.Calhelha Isabel C.F.R.Ferreira Lotfi Achour Adnane Kacem Maria Inês Dias Lillian Barros 
grateful to The Tunisian Ministry of High Education and research for financial support through national funds to Laboratory of Bioressources Integrative Biology and valorizatin;grateful the Foundation for Science and Technology(FCT,Portugal)for financial support through national funds FCT/MCTES to CIMO(UIDB/00690/2020)and SusTEC(LA/P/0007/2021);the F.Mandim PhD grant(SFRH/BD/146614/2019);L.Barros,M.I.Dias,and R.Calhelha thank the national funding by FCT,P.I.,through the institutional and S.A.Heleno to the individual scientific employment program-contract,for their contracts.
Suaeda fruticosa is an edible medicinal species belonging to the Amaranthaceae (Chenopodiaceae) family widely distributed in the Mediterranean regions, especially in Tunisia. This species shoots change their colour fr...
关键词：HALOPHYTE Suaeda fruticosa HPLC-DAD/ESI-MS O-glycosylated and acylated flavonoids BETALAINS BIOACTIVITIES 
A Glycosylated and Catechol-crosslinkedε-Polylysine Hydrogel:Simple Preparation and Excellent Wound Hemostasis and Healing Properties被引量：2
《Chinese Journal of Polymer Science》2022年第9期1110-1119,共10页Lin Teng Zheng-Wei Shao Yu-Shi He Jia-Yu Lu De-Rong Zou Chuan-Liang Feng Chang-Ming Dong 
financially supported by National Key Research and Development Project of China (No. 2021YFB4001101);the National Natural Science Foundation (NSFC) of China (No.22075176);Natural Science Foundation of Shanghai (No.22ZR1429200);NSFC projects (Nos. 51833006, 82071160,81870806 and 81974152)
Commercial tissue adhesives have been widely applied in wound hemostats and dressings while enhancing the hemostasis and healing capabilities is challenging to meet clinical needs.Herein,we designed the glucose-and ca...
关键词：Polylysine hydrogel Glycosylation Mussel-mimetic HEMOSTASIS Wound dressing 
Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles for ovalbumin delivery
《Chinese Chemical Letters》2022年第8期4084-4088,共5页Yingying Song Chang-Ming Dong 
the financial support of the National Natural Science Foundation of China(Nos.22075176 and21774074)。
Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles were disclosed for ovalbumin(OVA)delivery system.The mannose-coated polypeptide nanoparticles can induce st...
关键词：Polypeptide nanoparticles Sugar targeting Immune adjuvant Ovalbumin delivery system 
Multi-strategy engineering unusual sugar TDP-L-mycarose biosynthesis to improve the production of 3-O-α-mycarosylerythronolide B in Escherichia coli被引量：1
《Synthetic and Systems Biotechnology》2022年第2期756-764,共9页Zhifeng Liu Jianlin Xu Zhanguang Feng Yong Wang 
This study was financially supported by the National Key R&D Program of China(2018YFA0900600);the Program of Shanghai Academic Research Leader(20XD1404400);the Strategic Priority Research Program“Molecular mechanism of Plant Growth and Development”of CAS(XDB27020202);the National Natural Science Foundation of China(31670099);the Construction of the Registry and Database of Bioparts for Synthetic Biology of the Chinese Academy of Science(No.ZSYS-016);the International Partnership Program of Chinese Academy of Science(No.153D31KYSB20170121);the National Key Laboratory of Plant Molecular Genetics,SIPPE,CAS.
The insufficient supply of sugar units is the key limitation for the biosynthesis of glycosylated products.The unusual sugar TDP-L-mycarose is initially attached to the C3 of the polyketide erythronolide B,resulting i...
关键词：TDP-L-mycarose Glycosylated products 3-O-α-mycarosylerythronolide B Metabolic engineering CRISPRi 
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