supported by grants from National Key Research and Development Program of China(2018YFA0902000);National Natural Science Foundation of China(82173721);CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-029).
Digitoxose,a significant 2,6-dideoxyhexose found in nature,exists in many small-molecule natural products.These digitoxose-containing natural products can be divided into steroids,macrolides,macrolactams,anthracycline...
financial support from the National Natural Science Foundation of China(22177041,22277042,22077052,22107037,22207042);the China Postdoctoral Science Foundation(2021M691279);the 111 Project(111-2-06);the Max Planck Society International Partner Group Program,and the China Scholarship Council(CSC)for funding.P.H.S.thanks the Max Plank Society forgenerous financial support.
Helicobacter pylori(H.pylori)infection is a threat to human health.The lipopolysaccharide(LPS)O-antigen holds promise for developing vaccines.It is meaningful to explore the immunological activity of oligosaccharides ...
supported by the National Natural Science Foundation of China (Nos. 21472070 and 22177040);partly supported by the 111 Project (No. 111-2-06)。
Staphylococcus aureus wall teichoic acids(WTAs) are attractive targets for antibacterial vaccine development. In this study, three core glycosylated WTA structure, including α-1,4-Glc NAc, β-1,4-Glc NAc andβ-1,3-Gl...
financially supported by the Natural Science Foundation of China (Nos. 21502223, 81773580)
Phosphorylated di-,tri-and tetra-saccharides ofβ-1,2-mannan antigen derived from Candida albicans(C.albicans)cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin(KLH)and human serum alb...
supported by the National Natural Science Foundation of China(Nos.81773580,82003594);Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme to Guochao Liao(2019);the Department of education of Guangdong Province,China(No.2020KZDZX1057);the Science and Technology Planning Program of Guangzhou City,China(No.202008040004)。
A facile and efficient strategy was established for the construction of RC-529 and its derivatives.Four conjugates of RC-529 derivatives with Tn antigen were synthesized and all elicited strong and T celldependent imm...
the financial support from the National Key R&D Program of China(2017YFB0308402).
The glycoconjugates,herein glyco-proteins,existing in animal skins are closely related to the effectiveness of unhairing and fiber opening-up.Glycosidases have been used in leather making processes to reduce pollutant...
Indian Council of Medical Research, New Delhi, India, for the financial support provided in the form of Senior Research Fellowship (SRF-3/2/2/156/2011/NCD-Ⅲ)
Liver cancer is the fifth most common cancer and one of the leading causes of death in the world, and second most common cause of death in men. Natural products emerge as the most enduring approaches in the developmen...
Since the 1980s, the structure and function of natural glycocojugates have been understood in a brand new perspective; carbohydrates are recognized another important kind of compounds besides nucleic acids
Financial support from CNRS and MESER is gratefully acknowledged, as well as a fellowship from Chinese Scholarship Council to CHEN Jie
Carboxymethyl glycoside lactones(CMGLs) are bicyclic synthons which open readily for accessing new types of pseudo-glycoconjugates,such as sugar-amino acid hybrids,neoglycolipids,pseudodisaccharides,and membrane imagi...