Hainan Natural Science Foundation Youth Fund Project(No.818QN247);NSFC(No.81460550);Hainan Key Science and Technology Project(No.ZDYF2018154)
Objective:To investigate the effects and mechanisms of tetrahydroberberine(THB)on vascular endothelial cell injury induced by oxygen glucose deprivation(OGD)and LPS-induced cell injury model.Methods:MTT assay was used...
The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. C...
The carduc effects of THB were studied in uolated rught and left atrual prepa-rations from guinea pigs.In spontaneously beating right atrua,TH B(1-56.3μmal/L caused brady-card ia,which was not prevented by atropine(1...