VINPOCETINE

作品数：6被引量：8H指数：2
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相关领域：医药卫生更多>>
相关作者：钟慈声郑平魏苑梁子钧史念慈更多>>
相关机构：上海医科大学天津医科大学沈阳药科大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Acta Pharmacologica Sinica》《Chinese Chemical Letters》更多>>
相关基金：国家重点基础研究发展计划更多>>
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Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway
《Acta Pharmacologica Sinica》2025年第1期96-106,共11页Hong-qin Yang Zhi-wei Li Xi-xi Dong Jia-xin Zhang Jin Shan Min-jie Wang Jing yang Min-hui Li Jing Wang Hong-mei Zhao 
This study was supported by grants from the National High Level Hospital Clinical Research Funding(2022-PUMCH-D-002);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences grant,No.2021-12M-1-016;National Key Research and Development Program of China(2021YFE0190100).
Abdominal aortic aneurysm(AAA)is a degenerative disease that caused mortality in people aged>65.Senescence plays a critical role in AAA pathogenesis.Advances in AAA repair techniques have occurred,but a remaining prio...
关键词：abdominal aortic aneurysm VSMCS SENESCENCE VINPOCETINE SIRT1 
Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider被引量：1
《Asian Journal of Pharmaceutical Sciences》2023年第6期175-187,共13页Xin Shen Zhixiang Cui Yidan Wei Yingnan Huo Duo Yu Xin Zhang Shirui Mao 
supported by the Distinguished Professor Project of Liaoning Province.
The number of people with Alzheimer’s disease(AD)is increasing annually,with the nidus mainly concentrated in the cortex and hippocampus.Despite of numerous efforts,effective treatment of AD is still facing great cha...
关键词：VINPOCETINE BORNEOL NANOEMULSIONS Intranasal administration Brain targeting Brain subregion distribution 
Development and evaluation of vinpocetine inclusion complex for brain targeting被引量：2
《Asian Journal of Pharmaceutical Sciences》2015年第2期114-120,共7页Jiaojiao Ding Jinfeng Li Shirui Mao 
The objective of this paper is to prepare vinpocetine(VIN)inclusion complex and evaluate its brain targeting effect after intranasal administration.In the present study,VIN inclusion complex was prepared in order to i...
关键词：VINPOCETINE Hydroxypropyl-b-cyclodextrin Citric acid Inclusion complex Brain targeting 
Studies on the binding of vinpocetine to human serum albumin by molecular spectroscopy and modeling被引量：2
《Chinese Chemical Letters》2012年第5期599-602,共4页Hua Jiang Rong Rong Chen Hong Cui Wang Han Lin Pu 
The interaction between vinpocetine（VPC） and human serum albumin（HSA） in physiological buffer（pH 7.40） was investigated by fluorescence,FT-IR,UV-vis absorption and molecular modeling.VPC effectively quenched the...
关键词：VINPOCETINE Human serum albumin Fluorescence quenching Molecular modeling 
Inhibitory　effects　of　vinpocetine　on　sodium　current　in　rat　cardiomyocytes被引量：3
《中国药理学报》1997年第5期411-415,共5页魏苑 史念慈 钟慈声 郑平 梁子钧 
目的：研究长春西汀对心肌细胞钠电流的作用．方法：用全细胞膜片箝技术记录大鼠心肌细胞钠电流．结果：长春西汀可逆性抑制心肌细胞钠电流的作用为剂量依赖性和电压依赖性，但未发现频率或使用依赖性．长春西汀１０－８０μｍｏｌ·Ｌ...
关键词：长春西汀 钠通道 心肌 膜片箝 
长春西汀[Vinpocetine（卡兰CALAN）]的药理...
《沈阳医药》1993年第1期13-17,共5页许绍衡 李润兰 
关键词：长春西汀 药理 临床 
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