MISFOLDING

作品数：12被引量：5H指数：1
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相关领域：医药卫生生物学更多>>
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相关机构：中国科学院更多>>
相关期刊：《Open Journal of Biophysics》《Journal of Pharmacy and Pharmacology》《World Journal of Neurology》《Chinese Physics B》更多>>
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Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity
《Neural Regeneration Research》2024年第10期2095-2096,共2页Alessandro Cembran Pedro Fernandez-Funez 
supported by the NIH grant7R21 NS09662 7-02 to PFF;the Winston and Maxine Wallin Neuroscience Discovery Fund award CON000000083928 to PFF and AC。
The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of the...
关键词：FOLDING INTRINSIC DYNAMICS 
Alexander disease:the road ahead被引量：1
《Neural Regeneration Research》2023年第10期2156-2160,共5页María A.Pajares Elena Hernández-Gerez Milos Pekny Dolores Pérez-Sala 
Work at the authors’laboratories is supported by grants from"la Caixa"Foundation;Grant Agreement LCF/PR/HR21/52410002;EJP RD COFUND-EJP N°825575"Alexander"to DPS and MP;Agencia Estatal de Investigacion,MICINN and ERDF Grant No.RTI2018-097624-B-I00 and PID2021-126827OB-I00 to DPS;grants from the Swedish Research Council(2017-02255);ALF Gothenburg(146051);The Swedish Society for Medical Research,Hj?rnfonden,S?derberg’s Foundations,Hagstr?mer’s Foundation Millennium,Ami?v’s Foundation,E.Jacobson’s Donation Fund,the Swedish Stroke Foundation,NanoNet COST Action(BM1002),EU FP 7 Program TargetBraln(279017)to MP。
Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein,a type III intermediate filament protein expressed in astrocytes.Both early(infantile or juvenile)and a...
关键词：ASTROCYTES endoplasmic reticulum stress glial fibrillary acidic protein mutants metabolism misassembly MISFOLDING NEURODEGENERATION oxidative stress posttranslational modifications unfolded protein response 
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