Supported by the National Key Research and Development Program,No.2023YFF0713700 and No.2023YFF0713705;Common Technology R&D Platform of Shaanxi Province,No.2023GXJS-01-1-2;the Cyrus Tang Foundation Chung Ying Young Scholars Program.
BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver d...
National Natural Science Foundation of China(32171118,82370565,31671049,31371066);National Key New Drug Creation Program of China(2018ZX09711002-002-012);Shanghai Municipal Science and Technology Major Project(184319071000 and 19140903102);Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20211102).
Enteroendocrine cells(EECs)and vagal afferent neurons constitute functional sensory units of the gut,which have been implicated in bottom-up modulation of brain functions.Sodium oligomannate(GV-971)has been shown to i...
This work was supported in part by grants from National Key Research&Development Program of China(No.2022YFC3602102);Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(No.2021-1-I2M-050);National Natural Science Foundation of China(No.82170856);China Postdoctoral Science Foundation(No.2022M710456).
Glucagon-like peptide-1(GLP-1),a signal peptide hormone produced by enteroendocrine L cells from the distal small intestine and colon,is a crucial regulator of glycemic control,gastric emptying,satiety,and body weight...
Supported by the National Key Research and Development Program of China,No.2016YFA0100501;the National Natural Science Foundation of China,No.81770768 and No.81970671;and the Natural Science Foundation of Beijing,No.7192225.
Diabetes,one of the most common chronic diseases in the modern world,has pancreaticβcell deficiency as a major part of its pathophysiological mechanism.Pancreatic regeneration is a potential therapeutic strategy for ...
The pathophysiology of irritable bowel syndrome(IBS)is not completely understood.However,several factors are known to play a role in pathophysiology of IBS such as genetics,diet,gut microbiota,gut endocrine cells,stre...