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Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations被引量：4
《World Journal of Gastroenterology》2020年第35期5314-5327,共14页Bi-Xia Huang Yan Liu Zhen-Ping Fan Lan-Lan Si Rong-Juan Chen Jun Wang Dan Luo Fu-Sheng Wang Dong-Ping Xu Xin-Guang Liu 
the National Natural Science Foundation of China,No.81572010,No.81671399,No.81721002 and No.81971329;the Capital Health Research and Development of Special Fund Program,No.2016-2-5032;and the Beijing Natural Science Foundation No.7172206.
It is unclear whether immune escape-associated mutations in the major hydrophilic region of hepatitis B virus surface antigen(HBsAg)are associated with nucleoside/nucleotide analog resistance.AIM To evaluate the assoc...
关键词：Hepatitis B virus Immune escape-associated mutation Drug-resistance mutation Nucleoside/nucleotide analogs Hepatitis B surface antigen Major hydrophilic region 
Amplification of chromosome 21q22.3 harboring trefoil factor family genes in liver fluke related cholangiocarcinoma is associated with poor prognosis被引量：3
《World Journal of Gastroenterology》2006年第26期4143-4148,共6页Kanuengnuch Muenphon Temduang Limpaiboon Patcharee Jearanaikoon Chawalit Pairojkul Banchob Sripa Vajarabhongsa Bhudhisawasdi 
Supported by the Research Grants from Khon Kaen University, No. 48-03-1-01-03 the Center for Research and Development in Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, No 06-01
AIM： To determine allelic imbalance on chromosomal region 21q22-qter including trefoil factor family genes （TFF） in cholangiocarcinoma （CCA） patients and analyze the correlation between allelic imbalances and cli...
关键词：CHOLANGIOCARCINOMA Amplification on chromosome 21 Trefoil factor family Quantitative PCR Liver fluke 
Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes被引量：9
《World Journal of Gastroenterology》2001年第1期111-114,共4页Yi Ping Hu1 Wei Jiang Hu1 Wen Chao Zheng2 Jian Xiu Li1 De Shun Dai1 Xin Min Wang1 Shu Zhong Zhang1 Hong Yu Yu3 Wei Sun4 Guang Rong Hao4 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, China2University of Wisconsin, Madison, WI 53705, USA3Department of Pathology, Second Military Medical University, Shanghai 200433, China4Center of laboratory Animals, Second Military Medical University, Shanghai 200433, China 
This work was supported by Projects of Tackling Key Problems in Science;Technology from the State Science;Technology Ministry (TJ99-LA01); Shanghai Science;Technology Commission (994919033 )
INTRODUCTIONHepatitis B virus (HBV) belongs to the group ofhepatovirus, a major pathogen of human acute andchronic hepatitis B[1 4], which has a very closeassociation with human hepatocellular carcinoma(HCC)[5-8], For...
关键词：Genome  Viral Animals Antibodies  Viral DNA  Viral Disease Models  Animal Gene Expression Regulation  Viral Hepatitis B Hepatitis B Core Antigens Hepatitis B Surface Antigens Hepatitis B virus Kidney Liver MICE Mice  Transgenic MICROINJECTIONS Microscopy  Electron Polymerase Chain Reaction Research Support  Non-U.S. Gov't Virus Integration 
Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene被引量：14
《World Journal of Gastroenterology》1998年第6期81-84,共4页ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 
AIM To establish transgenic mice lineage xharboring hepatitis B virus X gene and to provide an efficient animal model for studying the exact role of the HBx gene in the process of hepatocarcinogenesis. METHODS ...
关键词：HEPATITIS B VIRUS gene  VIRAL TRANSGENIC animals liver neoplasms diseases models  animal 
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