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作品数:84被引量:159H指数:6
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相关领域:医药卫生农业科学更多>>
相关作者:张景昱叶梁宋艳茹王小桐更多>>
相关机构:中国科学院植物研究所南京军区南京总医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划福建省自然科学基金更多>>
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Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation被引量:1
《Science China(Life Sciences)》2021年第12期2144-2152,共9页Peng Bai Qiuping Zhou Pengcheng Wei Hua Bai Sanny K.Chan John W.Kappler Philippa Marrack Lei Yin 
supported by the National Natural Science Foundation of China(31870728,31470738,and 32000611);the National Basic Research Program of China(2014CB910103);the Fundamental Research Funds for the Central Universities(2042020kfxg02);the China Postdoctoral Science Foundation(2018M642918)。
Cytotoxic T cells targeting cancer neoantigens harboring driver mutations can lead to durable tumor regression in an HLAIdependent manner.However,it is difficult to extend the population of patients who are eligible f...
关键词:cancer immunology major histocompatibility complex(MHC) vaccine neoantigen prediction antigen immunogenicity 
Construction of a novel fusion protein harboring mouse inter- feron γ and epidermal growth factor receptor binding domain and enhancement of its antitumor activity被引量:1
《Science China(Life Sciences)》1997年第3期293-300,共8页丁炎平 谭维彦 胡荣 陈望秋 侯云德 
A novel fusion protein harboring mouse interferon γ and epidermal growth factor receptor binding domain was constructed with the method of genetic and protein engineering. The fusion protein kept complete antiviral a...
关键词:INTERFERON γ EPIDERMAL growth factor fusion protein ANTITUMOR activity. 
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