Ageing is accompanied by a decline in cellular proteostasis,which underlies many age-related protein misfolding diseases1,2.Yet,how ageing impairs proteostasis remains unclear.As nascent polypeptides represent a subst...
The journey of a newly synthesized polypeptide starts in the peptidyltransferase center of the ribosome, from where it traverses the exit tunnel. The interior of the ribosome exit tunnel is neither straight nor smooth...