PRESENILIN-1

作品数：23被引量：49H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：梅兵张冬丽陈逸群嵇婷婷王成志更多>>
相关机构：华东师范大学西南医科大学西南医科大学附属医院广西医科大学更多>>
相关期刊：《现代生物医学进展》《Acta Pharmacologica Sinica》《中华老年医学杂志》《Chinese Medical Journal》更多>>
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  • 期刊=Neural Regeneration Researchx
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Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease被引量：1
《Neural Regeneration Research》2023年第9期2019-2028,共10页Li-Fen Liu Yu-Tong Liu Dan-Dan Wu Jie Cheng Na-Na Li Ya-Ni Zheng Liang Huang Qiong-Lan Yuan 
supported by the Notional Natural Science Foundation of China,Nos.81371213 and 8107098 7;the Natural Science Foundation of Shanghai,No.21ZR1468400 (all to QLY)。
Extracellular amyloid beta(Aβ) plaques are main pathological feature of Alzheimer’s disease.However,the specific type of neuro ns that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown.In...
关键词：5-hydroxytryptamin receptor 3 Alzheimer’s disease amyloid beta plaques CALCINEURIN cognitive deficits HTR3 interneurons iCa2+ nuclear factor of activated T-cells transgenic amyloid precursor protein and presenilin-1 mice TROPISETRON 
Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's disease被引量：2
《Neural Regeneration Research》2013年第24期2249-2255,共7页Lihua Liu Saiping Luo Leping Zeng Weihong Wang Liming Yuan Xiaohong Jian 
supported by the National Natural Science Foundation of China, No. 81100663;the Scientific Research Funds of the Health Department of Hunan Province, No.120303;Hunan Provincal Natural Science Foundation of China, No. 13JJ3058;a grant from the Scientific Research Program of Hunan Provincial Higher Education Institutes, No. 11C0829
Mice carrying mutant amyloid precursor protein and presenilin-1 genes （APP/PS1 double trans- genic mice） have frequently been used in studies of Alzheimer＇s disease; however, such studies have focused mainly on hip...
关键词：neural regeneration PRESENILIN-1 Alzheimer＇s disease tyrosine hydroxylase locus coeruleus noradrenergic neuron ^-amyloid senile plaques grants-supported paper NEUROREGENERATION 
Cerebroprotective effect of Huanglian Jiedu decoction on amyloid protein precursor/presenilin-1 double transgenic mice
《Neural Regeneration Research》2011年第9期645-650,共6页Xin Qiu Guohua Chen Gui Mei Yuegu Wang Kaixin Wang Tao Wang Pei Feng 
the Natural Science Foundation of Hubei Province, No. 2007ABA060
Huanglian Jiedu decoction （HLJDD） has been shown to improve cerebral blood flow, and reduce lipid peroxidation damage to the brain and its energy metabolism. The present study was designed to observe the cerebroprot...
关键词：Huanglian Jiedu decoction amyloidprotein precursorlpresenilin-1 double transgenic mice effect HIPPOCAMPUS neural regeneration 
Mutant amyloid precursor protein and presenilin-1 genes effect on ischemia vulnerability via calcium homeostasis disturbance
《Neural Regeneration Research》2009年第12期1049-1054,共6页Liangyu Zou Xiaofan Chu Haiyan Yin Xuejun Fu Yiguang Rao Gang Li Yi Lu 
Supported by: Shenzhen Science Technology Project from Shenzhen Bureau of Science Technology and Information, No. 200702029;Medicial Science Technology Research Fund of Guangdong Province, No. A2008601 & A2007570
BACKGROUND： Previous studies have demonstrated that mutant amyloid precursor protein （APP） or presenilin-1 （PS1） genes increase susceptibility to ischemic brain damage induced by middle cerebral artery occlusion....
关键词：amyloid precursor protein PRESENILIN-1 cerebral ischemia calcium d 
Point mutation in exon 4 of presenilin-1 gene and early-onset familial Alzheimer disease被引量：1
《Neural Regeneration Research》2006年第6期493-496,共4页Yu Liao Fan Zhao 
BACKGROUND: A total of 50 missense mutations of presenilin-1 (PS-1) have been found thus far in early-onset familial Alzheimer disease (EOFAD), PS-1 gene might be a causative gene for Chinese EOFAD. OBJECTIVE: To inve...
关键词：外显子4 基因突变 阿尔兹海默症 病理机制 
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