LIDAMYCIN

作品数：19被引量：65H指数：6
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相关领域：医药卫生更多>>
相关作者：刘芳陈淑珍商悦甄永苏吴淑英更多>>
相关机构：中国医学科学院北京协和医学院中国医学科学院中国协和医科大学清华大学更多>>
相关期刊：《Science Bulletin》《中国抗生素杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金国家重点基础研究发展计划更多>>
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Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin被引量：6
《Science China(Life Sciences)》2011年第3期255-262,共8页FANG Hong MIAO QingFang ZHANG ShengHua CHENG Xin XIONG DongSheng ZHEN YongSu 
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02A255);the National Natural Science Foundation of China(Grant No. 30701029);the National Science and Technology Major Projects(Grant Nos.2009ZX09103-720 and 2010ZX09401-407)
Antibody-based fusion proteins are the next generation of antibody therapies for cancer and other diseases.CD20 antigen,which is overexpressed on cell membranes in nearly 95% of cases of B-cell Non-Hodgkin's Lymphoma,...
关键词：LYMPHOMA CD20 LIDAMYCIN SCFV energized fusion protein 
Lidamycin Induces Apoptosis of B-Cell Lymphoma Cells and Inhibits Xenograft Growth in Nude Mice
《Clinical oncology and cancer researeh》2009年第3期203-207,共5页Hong Fang Shenghua Zhang Qingfang Miao Dongsheng Xiong Yongsu Zhen 
supported by a grant from the National High Technology Research and Development Program of China(No.2006AA02A255).
OBJECTIVE To study the cytotoxicity of Lidamycin （LDM） and its induction of apoptosis in Raji and Daudi cells of B-cell lymphoma, and the inhibition of growth of the lymphoma Raji xenograft in nude mice. METHODS MTT...
关键词：lidamycin （LDM） LYMPHOMA B-CELL apoptosis. 
Synergy of gemcitabine and lidamycin associated with NF-κB downregulation in pancreatic carcinoma cells被引量：4
《Acta Pharmacologica Sinica》2008年第5期614-619,共6页Jing CHEN Shu-ying WU Zhi-gang OU-YANG Yong-su ZHEN 
This work was supported by The National High Technology Research and Development Program of China （No 2004AA2Z3950） and a grant from the National Natural Science Foundation of China （No 30400597）.
Aim： To investigate the effects on human pancreatic cancer PANC- 1 and SW1990 cells using a combination of lidamycin （LDM） and gemcitabine. Methods： A 3- （4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromid...
关键词：LIDAMYCIN GEMCITABINE pancreatic cancer K-RAS NF-ΚB drug therapy  combination 
Generation and antitumor effects of an engineered and energized fusion protein VL-LDP-AE composed of single-domain antibody and lidamycin被引量：3
《Science China(Life Sciences)》2007年第4期447-456,共10页MIAO QingFang, SHANG BoYang, OUYANG ZhiGang, LIU XiaoYun & ZHEN YongSu Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China 
Supported by the National High Technology Research and Development Program of China (863 Program)(Grant No. 2006AA02A255)
Type IV collagenase plays a pivotal role in invasion, metastasis and angiogenesis of tumor. Single domain antibodies are attractive as tumor-targeting vehicle because of their much smaller size com-pared with antibody...
关键词：type IV COLLAGENASE SINGLE-DOMAIN ANTIBODY LIDAMYCIN fusion protein antibody-based drugs 
Effect of Lidamycin on Telomerase Activity in Human Hepatoma BEL-7402 Cells被引量：3
《Biomedical and Environmental Sciences》2007年第3期189-197,共9页RUI-JUAN GAO YUE-XIN LIANG DIAN-DONG LI HONG-YIN ZHANG YONG-SU ZHEN 
This study was supported by the National High Technology Research and Development Program of China (863 Programm Grant No.2006AA02A255);the National Natural Science Foundation of China (Grant No.30472042; 30300424).
Objective To investigate the effect of lidamycin （LDM） on telomerase activity in human hepatoma BEL-7402 cells under the condition of LDM inducing mitotic cell death and senescence. Methods Chromatin condensation wa...
关键词：LDM Mitotic cell death Cellular senescence Telomerase activity 
Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma被引量：9
《World Journal of Gastroenterology》2005年第29期4478-4483,共6页Liang Li Yun-Hong Huang Yi Li Feng-Qiang Wang Bo-Yang Shang Yong-Su Zhen 
Supported by the National High Technology Research and Development Program of China, 863 Program, No. 2002AA2Z346D
AIM： Type IV collagenase including MMP-2 and -9 plays an important role in cancer cell invasion and metastasis and is an attractive target for rnAb-directed therapy. The irnrnunoreactivity of rnAb 3G11, a rnAb direct...
关键词：Type IV collagenase Monoclonal antibody Lidarnycin Colon carcinoma 
Antitumor efficacy of lidamycin on hepatoma and active moiety of its molecule被引量：20
《World Journal of Gastroenterology》2005年第26期3980-3984,共5页Yun-HongHuang Bo-YangShang Yong-SuZhen 
Supported by the National High Technology Research and Development Program of China (863 program), No. 2002AA2Z3107
AIM: To study the in vitro and in vivo antitumor effect of lidamycin (LDM) on hepatoma and the active moiety of its molecule.METHODS: MTT assay was used to determine the growth inhibition of human hepatoma BEL-7402 ce...
关键词：LIDAMYCIN HEPATOMA MITOMYCIN 
Tissue distribution and excretion of ^(125)I-lidamycin in mice and rats被引量：1
《World Journal of Gastroenterology》2005年第21期3281-3284,共4页You-PingLiu Quan-ShengLi Yu-RongHuang Chang-XiaoLiu 
Supported by the National High Technology Research and Development Program of China (863 Program), No. 2003AA2Z347D
AIM: To investigate the tissue distribution, urinary and fecal excretions of 125I-lidamycin (125I-C-1027) in mice and its biliary excretion in rats. METHODS:The total radioactivity assay (RA method) and the radioactiv...
关键词：Distribution EXCRETION LIDAMYCIN C-1027 RA method TCA-RA method 
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