云南高校图书馆联盟文献共享服务平台- LIDAMYCIN

LIDAMYCIN: 作品数：19被引量：65H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘芳陈淑珍商悦甄永苏吴淑英更多>>; 相关机构：中国医学科学院北京协和医学院中国医学科学院中国协和医科大学清华大学更多>>; 相关期刊：《Science Bulletin》《中国抗生素杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>; 相关基金：国家高技术研究发展计划国家自然科学基金国家重点基础研究发展计划更多>>

Site-specific PEGylation of lidamycin and its antitumor activity被引量：2: 《Acta Pharmaceutica Sinica B》2015年第3期264-269,共6页Liang Li Boyang Shang Lei Hu Rongguang Shao Yongsu Zhen; supported by the National Science and Technology Major Project for Major New Drug Innovation (Nos.2013ZX09102064 and 2014ZX09201042-003); In this study,N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein(r LDP) of lidamycin(LDM) was prepared using a polyethyleneglycol(PEG) derivative(Mw20 k Da) through a reactive terminal al...; 关键词：Enediyne antibiotic Polyethylene glycol Site-specific PEGylation LIDAMYCIN

Lidamycin inhibits tumor growth and pulmonary metastasis in murine breast carcinoma and shows synergy with paclitaxel: 《Chinese Science Bulletin》2013年第23期2805-2811,共7页HU Lei ZHANG ShengHua SHAO RongGuang ZHEN YongSu; supported by the Significant New Drugs Development Science and Technology Major Projects of China(2010ZX09401-407);State-level Public Welfare Scientific Research Institutes for Basic R&D Special Fund(IMBF201101); The main goal of this study was to investigate whether lidamycin (LDM) could enhance the efficacy of paclitaxel (TAX) against breast cancer. In the MTT assay, LDM showed much more potent cytotoxicity than paclitaxel, ...; 关键词：血管内皮生长因子乳腺癌细胞协同作用力达霉素紫杉醇抑制肿瘤肺小鼠

Role of Prosurvival Molecules in the Action of Lidamycin toward Human Tumor Cells: 《Biomedical and Environmental Sciences》2009年第3期244-252,共9页A-JING YANG WEI-WEI SHI YONG LI ZHEN WANG RONG-GUANG SHAO DIAN-DONG LI QI-YANG HE; supported by grants from the National Natural Science Foundation of China (No. 30672482);the National 973 Program (No. 2009CB521807); Objective Lidamycin, an enediyne antibiotic, leads to apoptosis and mitotic cell death of human tumor cells at high and low concentrations. The reason why tumor cells have distinct responses to lidamycin remains elusi...; 关键词：LIDAMYCIN Prosurvival molecules SIRTI deacetylase Apoptosis Mitotic cell death Multidrug resistance

Synergy of gemcitabine and lidamycin associated with NF-κB downregulation in pancreatic carcinoma cells被引量：4: 《Acta Pharmacologica Sinica》2008年第5期614-619,共6页Jing CHEN Shu-ying WU Zhi-gang OU-YANG Yong-su ZHEN; This work was supported by The National High Technology Research and Development Program of China （No 2004AA2Z3950） and a grant from the National Natural Science Foundation of China （No 30400597）.; Aim： To investigate the effects on human pancreatic cancer PANC- 1 and SW1990 cells using a combination of lidamycin （LDM） and gemcitabine. Methods： A 3- （4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromid...; 关键词：LIDAMYCIN GEMCITABINE pancreatic cancer K-RAS NF-ΚB drug therapy combination

Generation and antitumor effects of an engineered and energized fusion protein VL-LDP-AE composed of single-domain antibody and lidamycin被引量：3: 《Science China(Life Sciences)》2007年第4期447-456,共10页MIAO QingFang, SHANG BoYang, OUYANG ZhiGang, LIU XiaoYun & ZHEN YongSu Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Supported by the National High Technology Research and Development Program of China (863 Program)(Grant No. 2006AA02A255); Type IV collagenase plays a pivotal role in invasion, metastasis and angiogenesis of tumor. Single domain antibodies are attractive as tumor-targeting vehicle because of their much smaller size com-pared with antibody...; 关键词：type IV COLLAGENASE SINGLE-DOMAIN ANTIBODY LIDAMYCIN fusion protein antibody-based drugs

Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma被引量：9: 《World Journal of Gastroenterology》2005年第29期4478-4483,共6页Liang Li Yun-Hong Huang Yi Li Feng-Qiang Wang Bo-Yang Shang Yong-Su Zhen; Supported by the National High Technology Research and Development Program of China, 863 Program, No. 2002AA2Z346D; AIM： Type IV collagenase including MMP-2 and -9 plays an important role in cancer cell invasion and metastasis and is an attractive target for rnAb-directed therapy. The irnrnunoreactivity of rnAb 3G11, a rnAb direct...; 关键词：Type IV collagenase Monoclonal antibody Lidarnycin Colon carcinoma

Antitumor efficacy of lidamycin on hepatoma and active moiety of its molecule被引量：20: 《World Journal of Gastroenterology》2005年第26期3980-3984,共5页Yun-HongHuang Bo-YangShang Yong-SuZhen; Supported by the National High Technology Research and Development Program of China (863 program), No. 2002AA2Z3107; AIM: To study the in vitro and in vivo antitumor effect of lidamycin (LDM) on hepatoma and the active moiety of its molecule.METHODS: MTT assay was used to determine the growth inhibition of human hepatoma BEL-7402 ce...; 关键词：LIDAMYCIN HEPATOMA MITOMYCIN

Tissue distribution and excretion of ^(125)I-lidamycin in mice and rats被引量：1: 《World Journal of Gastroenterology》2005年第21期3281-3284,共4页You-PingLiu Quan-ShengLi Yu-RongHuang Chang-XiaoLiu; Supported by the National High Technology Research and Development Program of China (863 Program), No. 2003AA2Z347D; AIM: To investigate the tissue distribution, urinary and fecal excretions of 125I-lidamycin (125I-C-1027) in mice and its biliary excretion in rats. METHODS:The total radioactivity assay (RA method) and the radioactiv...; 关键词：Distribution EXCRETION LIDAMYCIN C-1027 RA method TCA-RA method

Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication被引量：12: 《World Journal of Gastroenterology》2004年第18期2632-2636,共5页Yue-XinLiang WeiZhang Dian-DongLi Hui-TuLiu PingGao Yi-NaSun Rong-GuangShao; Supported by Grants from the Major State Basic Research Development Program Foundation of China,No.G2000057010 and G 1999053901 and Grants from the National Natural Science Foundation of China,No.30271438 and 30300424 and Grant from the Key Laborator; AIM: Mitotic cell death has been focused on in tumor therapy.However, the precise mechanisms underlying it remain unclear. We have reported previously that enediyne antibiotic lidamycin induces mitotic cell death at l...; 关键词：细胞分裂细胞凋亡致死原因 BEL-7402细胞抗生素中心体肝细胞癌肿瘤

Effects of lidamycin on genomic DNA in human heptatoma BEL-7402 cells被引量：2: 《Acta Pharmacologica Sinica》2002年第3期253-256,共4页何琪杨姜兵李电东; Project supported by the National Natural Science Foundation of China (№ 30070878) and Major State Basic Research Development Program Foundation of China (№ G2000057010).; To further study the effect of enediyne antibiotic lidamycin (C1027) on genomic DNA in human hepatoma BEL-7402 cells. METHODS: The DNA patterns were detected by agarose gel electrophoresis. The gene damage was reveale...; 关键词：LIDAMYCIN antineoplastic agents DNA damage ras genes HEPATOMA

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