supported in part by an International Early Career Scientist grant from the Howard Hughes Medical Institute;the Beijing Scholar Program to Shao Feng;Other financial supports include the National Basic Research Program of China(2012CB518700),;the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB08020202);National Science Fund for Distinguished Young Scholars(31225002)to Shao Feng
Pyrin,encoded by MEFV gene,is conserved in humans and mice.Mutations in the MEFV gene are associated with the human autoinflammatory disease familial Mediterranean fever(FMF).Pyrin can interact with the inflammasome a...