INDAZOLE

作品数：13被引量：23H指数：3
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相关领域：医药卫生更多>>
相关作者：玄汉石金南革姜德华李在琉苗涛更多>>
相关机构：南京铁道医学院延边大学医学院附属医院延边大学淮北师范大学更多>>
相关期刊：《Chinese Journal of Chemical Physics》《Chinese Journal of Chemistry》《Crystal Structure Theory and Applications》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金王宽诚敎育基金更多>>
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Metal-Free Nitration of Indazoles with tert-Butyl Nitrile in Air to Prepare 3-Nitroindazoles and 3-Aminoindazoles
《Chinese Journal of Chemistry》2025年第4期393-398,共6页Xin-Yue Zhang Rong-Ting Jiang Xiu-Qun Pan Chun-Hua Chen Cui Liang Dong-Liang Mo 
the NSFC(22071035);Natural Science Foundation of Guangxi(2023GXNSFDA026025);Guangxi Bagui Young Scholar is greatly appreciated.
A variety of 3-nitroindazoles and 3-aminoindazoles were prepared in good to excellent yields with high regioselectivity through TBN-mediated nitration at the C3-position of indazoles under the air conditions and seque...
关键词：NITRATION INDAZOLE 3-Nitroindazole 3-Aminoindazole C-H Amination Radical reactions N-HETEROCYCLES Cleavage reactions 
I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations
《Chinese Chemical Letters》2025年第1期277-282,共6页You Zhou Li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang Zhi-Cheng Yu Xing Li Yan-Dong Wu Kai-Lu Zheng An-Xin Wu 
supported by the National Natural Science Foundation of China(Nos.21971080,22171098);supported by Chengdu Guibao Science&Technology Co.,Ltd.This work was also supported by the 111 Project(No.B17019)。
The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction conditions.The...
关键词：Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission 
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
《Acta Pharmacologica Sinica》2022年第7期1769-1779,共11页Ying Dong Bi-xi Tang Qi Wang Li-wei Zhou Cong Li Xuan Zhang Dan-dan Sun Xin Sun Xue-mei Zhang Bing Xiong Jia Li Hong Shi Dan-qi Chen Yi Zang 
This study was supported by National Natural Science Foundation of China(No.81773779,81125023,U1703235,31871414,and 81701220);Shanghai Science and Technology Development Funds(19JC1416300 and 18431907100);Key New Drug Creation_and Manufacturing_Program_of China(2019Zx09201001-004-010,2019Zx09201001-003-010,and 2018Zx09711002-004-009);Shanghai Aging and Maternal and Child Health Research Program(2020yizx0136);Backbone Program of Shanghai Pulmonary Hospital(fkgg1809)and K.C.Wong Education Foundation.
Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease characterized by destruction of lung parenchyma and deposition of extracellular matrix in interstitial and alveolar spaces.But known drugs for IPF are ...
关键词：idiopathic pulmonary fibrosis DDRs kinase inhibitor indazole derivatives XBLJ-13 nintedanib bleomycin-induced pulmonary fibrosismouse model 
Synthesis, Crystal Structure and Biological Activity of 1-(3-Amino-4-morpholino-1H-indazole-1-carbonyl)-N-(4-fluorophenyl)cyclopropane-1-carboxamide被引量：3
《Chinese Journal of Structural Chemistry》2019年第11期1889-1894,共6页JI Xiao-Hui ZHAO Juan LU Jiu-Fu JIN Ling-Xia GE Hong-Guang 
Supported by the Team of Syngas Catalytic Conversion of Shaanxi University of Technology;the Youth National Natural Science Foundation of China(No.21373132,21603133);the key project of education department of Shaanxi province(18JS023);the Project of Shaanxi Provincial Science and Technology Department(2019JQ149,2019JM471);the project of Shaanxi University of technology(SLGQD2017-14)
The title compound 1-(3-amino-4-morpholino-1H-indazole-1-carbonyl)-N-(4-fluorophenyl)cyclopropane-1-carboxamide was synthesized by the condensation of 1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid with 4...
关键词：INDAZOLE SYNTHESIS X-ray diffraction biological activity 
Synthesis, Rietveld Refinement and DFT Studies of Bis(4,5-dihydro-1<i>H</i>-benzo[g]indazole)silver(I) Hexafluorophosphate Complex Salt
《Open Journal of Inorganic Chemistry》2017年第4期102-115,共14页Tanyi Rogers Fomuta Jean Ngoune Golngar Djimassingar Tayo Alain Djampouo Junior Ma Ntep Tobie Matemb Jean Jacques Anguile Justin Nenwa 
The new salt bis(4,5-dihydro-1H-benzo[g]indazole)silver(I) hexafluorophosphate, [Ag(N2H10C11)2]PF6, has been synthesized in methanol at ambient temperature and characterized by elemental and thermal analyses, FTIR and...
关键词：SILVER Complex Salt 4 5-dihydro-1H-benzo[g]indazole 1HNMR Powder Diffraction Rietveld Refinement DFT 
β-Cyclodextrin as a supramolecular catalyst for the synthesis of 2Hindazolo[2,1-b]phthalazine-trione derivatives in water and their antimicrobial activities被引量：2
《Chinese Chemical Letters》2017年第7期1577-1582,共6页Asha V.Chate Priyanka K.Bhadke Manisha A.Khande Jaiprakash N.Sangshetti Charansingh H.Gill 
supported by Special Assistance Programme SAP,University Grants Commission,New Delhi,India
An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol%β-cyclodextrinvia a one-pot multicomponent reaction of aldehyde,dimedone,hydr...
关键词：Multicomponent reactions（MCRs） Pyridazino[1 2-a]indazole-triones 2H-Indazolo[2 1-b]phthalazine-trione β-Cyclodextrin Aqueous medium Green method Antimicrobial activity 
Synthesis, Structural Characterization and DFT Studies of Silver(I) Complex Salt of Bis(4,5-dihydro-1<i>H</i>-benzo[g]indazole)被引量：1
《Crystal Structure Theory and Applications》2017年第2期11-24,共14页Tanyi Rogers Fomuta Golngar Djimassingar Jean Ngoune Nana Odette Ngnabeuye Jean Jacques Anguile Justin Nenwa 
A new silver complex salt [Ag(N2C11H10)2]NO3 (where N2C11H10 = 4,5-dihydro-1H-benzo[g]indazole), has been synthesized and characterized by elemental and thermal analyses, IR and 1HNMR spectroscopies, single crystal X-...
关键词：SILVER Complex Salt 4 5-dihydro-1H-benzo[g]indazole Hydrogen Bonds THERMOGRAVIMETRIC Analysis 1HNMR X-Ray DFT Studies 
Synthesis and biological evaluation of substituted indazolyl amide derivatives as S-adenosyl-L-homocysteine hydrolase inhibitors
《Chinese Chemical Letters》2016年第6期984-988,共5页Xiang-Duan Tan Li-Guang Mao Wei Wu Si-Yun Nian Guo-Ping Wang 
supported by National Natural Science Foundation of China (No. 81560653);Guangxi Natural Science Foundation of China (No. 2015GXNSFBA139124)
A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S-adenosylL-homocysteine hydrolase（SAHase） inhibitory activity. Among these compounds, 8b,8m, 8r and 8...
关键词：S-Adenosylhomocysteine hydrolase SAHase inhibitors Amide derivatives INDAZOLE SYNTHESIS 
DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes被引量：5
《Acta Pharmacologica Sinica》2016年第5期604-616,共13页Tian-yi YUAN Yu-cai CHEN Hui-fang ZHANG Li LI Xiao-zhen JIAO Ping XIE Lian-hua FANG Guan-hua DU 
Aim： DL0805-2 [N-（1H-indazol-5-yl）-1-（4-methylbenzyl） pyrrolidine-3-carboxamide] is a DL0805 derivative with more potent vasorelaxant activity and lower toxicity. This study was conducted to investigate the vasor...
关键词：DL0805-2 angiotensin II VASORELAXATION Rho/ROCKs Ca^2＋ fluxes rat aortic ring vascular smooth muscle cells 
An Effective Synthesis of Indazolo[2,1-a]indazole-6,12-diones by Regioselective Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process
《Chinese Journal of Chemistry》2011年第12期2769-2774,共6页王治明 于斌 崔源 孙小强 包伟良 
Project supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the National Natural Science Foundation of China （Nos. 21072168, 21102009） and Natural Science Foundation of Jiangsu Province （No. BK2011230）.
A new and efficient cascade synthesis of indazolo[2,1-a]indazole-6,12-diones has been developed. This protocol includes an intermolecular N-acylation followed by a copper-catalyzed intramolecular C--N coupling reactio...
关键词：Indazolone derivatives cascade reaction copper（I） catalyst 2-halobenzoyl chlorides 
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