PHOSPHODIESTERASE

作品数:79被引量:148H指数:6
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相关领域:医药卫生更多>>
相关作者:朱永通徐雯曹云燕崔倩倩蔡圣朝更多>>
相关机构:南方医科大学南方医院浙江大学安徽中医药大学华中农业大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家科技支撑计划北京市自然科学基金更多>>
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S1-6 PDE4 Inhibitor Ameliorates Neuropathic Pain by Upregulating Spinal Connexin 43 Expression
《神经药理学报》2018年第4期8-9,共2页ZHANG Fang-fang ZHOU Yan-memg WANG Hao GAO Shan WANG Lei TAN Rui DU Xian ZHAO Xiao-min ZHANG Han-ting 
Peripheral nerve injury downregulates connexin43(Cx43)expression in spinal astrocytes.Therefore,restoration of spinal astrocyte Cx43 expression to normal levels could lead to the reduction of nerve injury-induced pain...
关键词:phosphodiesterase-4(PDE4) CONNEXIN43 ROLIPRAM ROFLUMILAST NEUROPATHIC pain 
S1-7 Inhibition of Phosphodiesterase-2 Activity in the Amygdala Produces Anxiolytic-Like Effects in Mice
《神经药理学报》2018年第4期9-10,共2页CHEN Ling CHENG Zi-juan JIN Ji LI Qing-yu WANG Gang 
Objective To explore the role of phosphodiesterase-2 activity in the amygdala produces anxiolytic-like effects in mice.Methods:Male ICR mice were implanted with guide cannula targeting the central nucleus of the amygd...
关键词:phosphodiesterase-2 ANXIETY BAY 60-7550 AMYGDALA microRNA MICE 
S2A-5 Targeting PDE4 for Alzheimer’s Disease and Alcoholism:An implication in Alcohol-Related Dementia?
《神经药理学报》2018年第4期39-41,共3页WANG Hao ZHANG Fang-fang FU Hua-rong ZHOU Yan-meng LIU Xin HOU Xue-qin HU Wei Rolf Hansen XU Ying James O’Donnell 张汉霆 
Background:Phosphodiesterase 4(PDE4),one of the 11 PDE enzyme families that hydrolyze cyclic nucleotides,is critical for controlling intracellular cyclic AMP(cAMP)concentrations and plays an important role in regulati...
关键词:Phosphodiesterase-4(PDE4) Alzheimer’s disease(AD) ALCOHOLISM cAMP signaling memory trangenic mice 
S3A-4 Inhibition of Phosphodiesterase 4 by FCPR16 Protects SH-SY5Y Cells against MPP^+-Induced Cell Death through Activating cAMP/PKA/CREB and Epac/Akt Signaling Pathways
《神经药理学报》2018年第4期54-55,共2页ZHONG Jia-hong WANG Hai-tao XU Jiang-ping 
Background:Phosphodiesterase 4(PDE4)is a promising target for the treatment of Parkinson’s disease(PD).However,the underlying mechanism has not yet been well elucidated.Additionally,most of current PDE4 inhibitors pr...
关键词:PHOSPHODIESTERASE 4 FCPR16 Oxidative stress Mitochondrial membrane potential Parkinson’s disease 
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