TRIPLEX

作品数：41被引量：37H指数：3
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Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells
《Chinese Chemical Letters》2024年第9期219-222,共4页Yan Liu Yang Wang Jiayi Zhu Xuxian Su Xudong Lin Liang Xu Xiwen Xing 
supported by the National Key R&D Program of China(Nos.2022YFC2804101,2020YFA0211200);National Natural Science Foundation of China(Nos.22377056,22222706,21977122)。
The clustered regularly interspersed short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)system is an RNA-guided platform for highly efficient and specific genome targeting in diverse organisms,which has...
关键词：RNA triplex PH-RESPONSIVE CRISPR/Cas9 Gene manipulation Eukaryotic cells 
Toeless and reversible DNA strand displacement based on Hoogsteen-bond triplex
《Chinese Chemical Letters》2024年第5期330-337,共8页Yang Qin Jiangtian Li Xuehao Zhang Kaixuan Wan Heao Zhang Feiyang Huang Limei Wang Hongxun Wang Longjie Li Xianjin Xiao 
financially supported by the National Key Research and Development Program of China(No.2021YFC2701402);the Open Research Fund of State Key Laboratory of Bioelectronics,Southeast University(No.Sklb2021-k06);the Open Foundation of NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Maternal and Child Health Care Hospital)(No.KF2020007);the Open Foundation of Translational Medicine National Science and Technology Infrastructure(Shanghai)(No.TMSK-2021-141)。
Strand displacement reaction is a crucial component in the assembly of diverse DNA-based nanodevices,with the toehold-mediated strand displacement reaction representing the prevailing strategy.However,the single-stran...
关键词：DNA strand displacement Toeless Triplex DNA strands REVERSIBLE DNA circuit DNA walker 
Triplex-structure based DNA circuits with ultra-low leakage and high signal-to-noise ratio
《Chinese Chemical Letters》2024年第1期465-470,共6页Huan Liu Zhihao Ming Yuanpeng Zhang Qidong Xia Hao Hu Ruijie Liu Yuheng Liao Yizhou Liu Xiao Liu Xiaoping Zhang Longjie Li Shaogang Wang Xianjin Xiao 
the National Natural Science Foundation of China(No.81871732);the National Key Research and Development Program of China(No.2021YFC2701402);the Open Research Fund of State Key Laboratory of Bioelectronics,southeast University(No.Sklb2021-k06);the Open Foundation of NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Maternal and Child Health Care Hospital)(No.KF2020007);the Open Foundation of Translational Medicine National Science and Technology Infrastructure(Shanghai)(No.TMSK-2021-141);the Open Fund from Key Laboratory of Cellular Physiology(Shanxi Medical University);Ministry of Education,China(No.CPOF202103).
DNA circuits are powerful tools in various applications such as logical computation,molecular diagnosis and synthetic biology.Leakage is a major problem in constructing complex DNA circuits.It directly affects the out...
关键词：LEAKAGE DNA strand displacement cascades TRIPLEX DNA circuits Molecular programming 
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