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作品数：184被引量：230H指数：7
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相关作者：李曙光刘杰周宝刚翁羽翔展雪梅更多>>
相关机构：南京师范大学浙江科技学院杭州职业技术学院中国科学院更多>>
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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease
《Neural Regeneration Research》2025年第11期3193-3206,共14页Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou 
supported by Singapore National Medical Research Council(NMRC)grants,including CS-IRG,HLCA2022(to ZDZ),STaR,OF LCG 000207(to EKT);a Clinical Translational Research Programme in Parkinson's Disease;Duke-Duke-NUS collaboration pilot grant(to ZDZ)。
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogene...
关键词：dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches 
Agents with foundation models:advance and vision
《Frontiers of Computer Science》2025年第4期119-120,共2页Chenghua GONG Xiang LI 
1 Introduction With rapid development in computing power and breakthroughs in deep learning,the concept of“foundation models”has been introduced into the AI community.Generally,foundation models are large models tra...
关键词：computing power foundation models adapted different domains animate scenarios deep learningthe massive data generate texts imagesor deep learning 
Tnni3k regulates cardiomyopathy and cardiac conduction disease through Nfatc1 signaling
《Genes & Diseases》2025年第3期50-53,共4页Shi Ouyang Yujuan Niu Le Liu Qiaorong Yi Wuming Qin Hui Cao Tao Liao Rong Xiang Yonghe Ding Yun Deng 
supported in part by the National Natural Science Foundation of China(No.31970504,31772548,82371863,82070394);the NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Maternal and Child Health Care Hospital)(No.KF2021003);the Postgraduate Scientific Innovation Fund of Hunan Province,China(No.CX2018B302).
TNNI3K(troponin-I interacting kinase)encodes a duo tyrosine and serine/threonine kinase implicated in cardiomyopathy,arrhythmias,and cardiac conduction disease(CCD).1 However,no direct downstream phosphorylation targe...
关键词：generate splicing mutation splicing mutation zebrafish tnni k ortholog gene tnni k direct downstream phosphorylation targets cardiac conduction disease ccd CARDIOMYOPATHY nfatc signaling 
TaxDiff:taxonomic-guided diffusion model for protein sequence generation
《Science China(Information Sciences)》2025年第4期381-382,共2页Zongying LIN Hao LI Liuzhenghao LV Yu WANG Bin LIN Junwu ZHANG Zijun CHEN Calvin Yu-Chian CHEN Li YUAN Yonghong TIAN 
supported in part by National Natural Science Foundation of China(Grant Nos.62425101,62088102,62202014);Shenzhen Science and Technology Program(Grant No.KQTD20240729102051063)。
Protein design aims to generate protein variants with targeted biological functions,which is significant in multiple biological areas,including enzyme reaction catalysis,vaccine design,and fluorescence intensity.Prote...
关键词：enzyme reaction catalysisvaccine designand generate protein variants targeted biological functionswhich structure generationrecentlyevodiff proposed structure sequence generation fluorescence intensityprotein design diffusion frameworkwhich sequence generation protein design 
Internal solitary waves in the Shenhu continental shelf slope break zone of the northern South China Sea generate benthic storms
《Science China Earth Sciences》2025年第3期928-942,共15页Yonggang JIA Xuezhi FENG Chaoqi ZHU Linsen WANG Xiaolei LIU Cong HU Hongwei WANG 
the National Natural Science Foundation of China for supporting open scientific expeditions in the northern South China Sea (NORC2020-05, NORC2022-05);supported by the National Natural Science Foundation of China (Grant Nos. 41831280, 42207173);the Natural Science Foundation of Shandong Province (Grant No. ZR2022QD002)。
Internal solitary waves can generate intense bottom currents and turbulent mixing over continental slopes, influencing the redistribution of sediments and pollutants, as well as driving changes in marine geomorphology...
关键词：Internal solitary waves Benthic storms Shear stress Suspended sediment flux Fluvial sediment flux 
Graphene oxide-based nanofluidic membranes for reverse electrodialysis that generate electricity from salinity gradients
《Carbon Energy》2025年第1期36-51,共16页Changchun Yu Yiming Xiang Tom Lawson Yandi Zhou Pingan Song Shulei Chou Yong Liu 
Key Research and Development Program of Zhejiang Province,Grant/Award Number:2021C04019;National Natural Science Foundation of China,Grant/Award Number:U20A20338;Natural Science Foundation of Zhejiang Province,Grant/Award Number:LQ21H180012.
A widely employed energy technology,known as reverse electrodialysis(RED),holds the promise of delivering clean and renewable electricity from water.This technology involves the interaction of two or more bodies of wa...
关键词：graphene oxide ion gradients nanofluidic membranes reverse electrodialysis salinity gradient power 
Comparative analysis of recent hydrological models and an attempt to generate new combined products for monitoring terrestrial water storage change
《Geodesy and Geodynamics》2024年第6期616-626,共11页Yang Lu Zhao Li Qusen Chen Meilin He Ze Wang Jian Wang Weiping Jiang 
funded by the National Natural Science Foundation of China (42174030);Major Science and Technology Program for Hubei Province (Grant No.2022AAA002);Special fund of Hubei Luojia Loboratory (220100020);the National Natural Science Foundation of China under Grant 42304031;the China Postdoctoral Science Foundation 2022M722441。
Hydrological models are crucial for characterizing large-scale water quantity variations and correcting GNSS reference station vertical displacements.We evaluated the robustness of multiple models,such as the Global L...
关键词：Hydrological model Variance component estimation GPS GPCC Satellite gravity field Mascon Terrestrial water storage changes Signal-to-noise ratio 
Multi3D:3D-aware multimodal image synthesis
《Computational Visual Media》2024年第6期1205-1217,共13页Wenyang Zhou Lu Yuan Taijiang Mu 
supported by the National Science and Technology Major Project(Grant No.2021ZD0112902);the National Natural Science Foundation of China(Project No.62220106003);a Research Grant from Beijing Higher Institution Engineering Research Center,and Tsinghua–Tencent Joint Laboratory for Internet Innovation Technology.
3D-aware image synthesis has attained high quality and robust 3D consistency.Existing 3D controllable generative models are designed to synthesize 3D-aware images through a single modality,such as 2D segmentation or s...
关键词：generate adversarial networks(GANs) neural radiation field(NeRF) 3D-aware image synthesis controllable generation 
VA-Creator-A Virtual Appliance Creator based on adaptive Neural Networks to generate synthetic power consumption patterns
《Energy and AI》2024年第4期160-200,共41页Michael Meiser Benjamin Duppe Ingo Zinnikus Alexander Anisimov 
funded by the German Federal Ministry for Economic Affairs and Climate Action(BMWK)as part of the ForeSightNEXT project;by the German Federal Ministry of Education and Research(BMBF)as part of the ENGAGE project.
With the advent of the Smart Home domain and the increasingly widespread application of Machine Learning(ML),obtaining power consumption data is becoming more and more important.Collecting real-world energy data using...
关键词：Smart Home Synthetic Sensor Data Energy data Virtual Appliance Machine Learning Neural Networks Multilayer Perceptron Generative Adversarial Network Dynamic Time Warping Transfer Learning Non-Intrusive Load Monitoring NILMTK 
DNA-based nanosystems to generate reactive oxygen species for nanomedicine被引量：1
《Chinese Chemical Letters》2024年第11期25-34,共10页Zhongyu Wang Lijun Wang Huaixin Zhao 
financial support provided by the National Key R&D Program of China(No.2022YFC2603800);the National Natural Science Foundation of China(No.22274113)。
Reactive oxygen species(ROS)are essential in various pathological and physiological processes.Developing nanosystems that generate ROS in a controlled manner is of great interest for nanomedicine.DNA nanotechnology of...
关键词：DNA nanotechnology Photodynamic therapy Chemodynamic therapy Reactive oxygen species Nanomedicine 
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