ISLETS

作品数：51被引量：100H指数：6
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相关领域：医药卫生更多>>
相关作者：沈坤堂吴人亮更多>>
相关机构：复旦大学中南大学湘雅三医院首都医科大学同济医科大学更多>>
相关期刊：《Chinese Medical Journal》《外科研究与新技术（中英文）》《Journal of Pancreatology》《Journal of Diabetes Mellitus》更多>>
相关基金：国家自然科学基金中国博士后科学基金云南省应用基础研究基金国家重点基础研究发展计划更多>>
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Epinephrine also acts on beta cells and insulin secretion
《World Journal of Clinical Cases》2024年第9期1712-1713,共2页Lina Zabuliene Ioannis Ilias 
In a recent review examining neurotransmitter modulation of insulin secretion,the significant impact of epinephrine was not addressed.Its primary action involves inhibiting insulin release via alpha-adrenergic recepto...
关键词：EPINEPHRINE INSULIN ISLETS GLUCOSE Human 
Dietary Green Tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis
《Open Journal of Endocrine and Metabolic Diseases》2024年第2期53-72,共20页Galande Sheethal Ranjeet K. Tokala Pavan Pondugala Krishna Vemula Vijayalakshmi Venkatesan Pothani Suresh Surya Satyanarayana Singh Guduru Venkat Rao Duvvur Nageshwar Reddy Mitnala Sasikala 
Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to...
关键词：Dietary Intervention C57BL6/J Mice Epigallocatechin-3-Gallate N-Acetyl Cysteine CURCUMIN Chronic Pancreatitis ISLETS Glucose Stimulated Insulin Secretion 
A novel bioartificial pancreas fabricated via islets microencapsulation in anti-adhesive core-shell microgels and macroencapsulation in a hydrogel scaffold prevascularized in vivo被引量：1
《Bioactive Materials》2023年第9期362-376,共15页Haofei Li Yulian Shang Qi Feng Yang Liu Junlin Chen Hua Dong 
sponsored by the National Natural Science Foundation of China(Grant Nos.51873071,32071321);the National Key Research and Development Program of China(2018YFC1106300).
Islets transplantation is a promising treatment for type 1 diabetes mellitus. However, severe host immune rejection and poor oxygen/nutrients supply due to the lack of surrounding capillary network often lead to trans...
关键词：Type 1 diabetes Bioartificial pancreas Islet encapsulation Core-shell microgel Prevascularized scaffold 
Intermittent protein restriction protects isletβcells and improves glucose homeostasis in diabetic mice被引量：4
《Science Bulletin》2022年第7期733-747,共15页Siying Wei Chenchen Li Xuemei Luo Lanzexin Yang Long Yu Qintao Wang Zhuo-Xian Meng Tao Wang Yan Chen 
supported by the National Natural Science Foundation of China (31630036);the Ministry of Science and Technology of China (2016YFA0500103);the Chinese Academy of Sciences (QYZDJ-SSW-SMC008)
Diabetes is caused by the interplay between genetics and environmental factors, tightly linked to lifestyle and dietary patterns. In this study, we explored the effectiveness of intermittent protein restriction(IPR)in...
关键词：Nutritional intervention Diabetes intervention Protein restriction ISLETS scRNA-seq 
Pseudotime Ordering Single-Cell Transcriptomic ofβCells Pancreatic Islets in Health and Type 2 Diabetes
《Phenomics》2021年第5期199-210,共12页Kaixuan Bao Zhicheng Cui Hui Wang Hui Xiao Ting Li Xingxing Kong Tiemin Liu 
supported by the National Key R&D Program of China(2019YFA0801900,2018YFA0800300);the National Natural Science Foundation of China(31971074);the Science and Technology Innovation Action Plan of Shanghai Science and Technology Committee(18140901300);the Open Research Fund of the National key laboratory of genetic engineering(SKLGE1803);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);Shanghai Frontiers Science Research Base of Exercise and Metabolic Health.
βcells are defined by the ability to produce and secret insulin.Recent studies have evaluated that human pancreaticβcells are heterogeneous and demonstrated the transcript alterations ofβcell subpopulation in diabe...
关键词：Single-cell RNA seq ISLETS βcell Pseudotime T2D 
Erastin-induced ferroptosis is a regulator forthe growth and function of humanpancreatic islet-like cell clusters被引量：3
《Cell Regeneration》2020年第1期171-179,共9页Xing Yu Li Po Sing Leung 
This research was supported by the General Research Fund of The Research Grants Council of Hong Kong(Ref.#14107415);The Chinese University of Hong Kong(Ref.#CUHK7104280)to PS Leung.
Ferroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactiveoxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently propo...
关键词：Apoptosis Autophagy Cell death Erastin Ferrostatin-1 ISLETS NOX4 P38 
Total pancreatectomy with islet autotransplantation in diabetic and pre-diabetic patients with intractable chronic pancreatitis
《Journal of Pancreatology》2020年第2期86-92,共7页Bachul Piotr J. Grybowski Damian J. Anteby Roi Basto Lindsay Perea Laurencia Golab Karolina Wang Ling-Jia Tibudan Martin Gutierrez Angelica P. Komorniczak Michal Nagpal Sajan Lucander Aaron Fung John Matthews Jeffrey B. Witkowski Piotr 
The Work was supported by Islet Core University of Chicago Diabetes Research and Training Center,US Public Health Service Grant P30DK020595.
Total pancreatectomy with islet autotransplantation(TPIAT)is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis.The outcome and potential benefits for pre-diabetic and diabet...
关键词：AUTOTRANSPLANTATION ISLETS Outcomes PANCREATECTOMY PRE-DIABETES 
Formation Mechanism of Beach Rocks and Its Controlling Factors in Coral Reef Area, Qilian Islets and Cays,Xisha Islands, China被引量：1
《Journal of Earth Science》2019年第4期728-738,共11页Na Zhao Dishu Shen Jian-Wei Shen 
supported by the National Natural Science Foundation of China (Nos. 41672107, 41372119, 41440040);supports provided by the Marine Environmental Observation and Research Station at the Xisha Islands, the South China Sea Institute of Oceanology, CAS during the fieldwork
Beach rock,which forms at the intertidal zone,is a natural barrier to protect beach and island from wave erosion. The formation mechanism of beach rocks is significant in the study of surface carbonate diagenesis and ...
关键词：BEACH rock CEMENTATION micritization coral REEF QILIAN ISLETS and Cays the South China Sea 
The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2被引量：7
《Protein & Cell》2019年第6期436-449,共14页Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang 
supported by research grants from the National Natural Science Foundation of China(31600953 to X.Wang;31530034 and 31330036 to F.Wang,31570791 and 91542205 to J.Min);the National Key R&D Program of China(2018YFA0507801 to J.Min and 2018YFA0507802 to F.Wang);the Zhejiang Provincial Natural Science Foundation of China(LQ15C110002 to X.Wang and LZ15H160002 to J.Min);the Nation Science and Technology Major Projects for Major New Drugs Innovation and Develop 2017ZX09101-005-004-002(L.Chen).
Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-ce...
关键词：ZINC ZINC TRANSPORTER PANCREATIC ISLETS β-cells insulin secretion 
Transcriptome Profiles and Gene Expression of Min6 Cells Are Altered by Pancreatic Stellate Cells
《Advances in Bioscience and Biotechnology》2018年第6期273-288,共16页Ratnakar Reddy Bynigeri Sasikala Mitnala Ravikanth Vishnubhotla Rupjyoti Talukdar Surya Satyanarayana Singh Nageshwar Reddy Duvvuru 
Aim: To identify the influence of pancreatic stellate cell (PSCs) secretions on gene expression profiles of Min6 cells by whole transcriptome sequencing. Methods: Pancreatic stellate cells (PSCs) were isolated from C5...
关键词：β-Cells Gene Expression ISLETS PANCREATIC Stellate Cells Tran-scriptome 
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