2-METHOXYESTRADIOL

作品数：8被引量：17H指数：2
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相关领域：医药卫生更多>>
相关作者：夏鹏涂三芳卢晓牛新清蒋皓更多>>
相关机构：复旦大学南方医科大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《吉林大学学报（医学版）》《Acta Pharmacologica Sinica》《Oncology and Translational Medicine》更多>>
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Association of 2-methoxyestradiol levels with the occurrence and development of endometrial cancer in humans
《Oncology and Translational Medicine》2022年第4期191-195,共5页Huanhuan Zhao Junyu Li Yan Liu Li Li 
Supported by the Hebei Province Medical Science Research Key Project(No.20210276).
Objective The aim of the study was to determine the association of urinary levels of estradiol(E_(2))and 2-methoxyestradiol(2-MeOE_(2))with the occurrence and development of endometrial cancer.Methods In this case-con...
关键词：endometrial cancer 2-methoxyestradiol(2-MeOE_(2)) estradiol(E_(2)) URINE high-performance liquid chromatography-mass spectrometry(HPLC-MS) 
The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E(eIF4E)and inhibits protein synthesis in MG63 osteosarcoma cells
《Genes & Diseases》2016年第2期153-158,共6页Avudaiappan Maran Kristen L.Shogren Michael J.Yaszemski 
Osteosarcoma is a primary bone tumor that affects children and young adults.The estrogen metabolite 2-methoxyestradiol(2-ME)induces cell death in osteosarcoma cells.To determine whether 2-ME actions involve the contro...
关键词：2-METHOXYESTRADIOL 4E-BP Estrogen metabolite EIF4E OSTEOSARCOMA 
Synthesis and VEGF inhibitory activity of 16,17-pyrazo-annulated steroids
《Chinese Chemical Letters》2011年第7期757-760,共4页Hong Shan Liu Hu Ling Zheng Mei Ge Peng Xia Ying Chen 
supported by grants from the National Natural Science Foundation of China awarded to P.Xia (No.20272010) and Y.Chen(No.30200348 and 30873164);the National Drug Innovative Program(No.2009ZX09301-011) for partial support
Eight 16,17-pyrazo-annulated steroidal derivatives were synthesized and evaluated in vitro vascular endothelial growth factor （VEGF） inhibitory activity with 2-methoxyestradiol （2-ME） as the reference compound. Mo...
关键词：Pyrazo-annulated steroid 2-Methoxyestradiol （2-ME） VEGF inhibitory activity 
2-Methoxyestradiol blocks cell-cycle progression at the G2/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells被引量：3
《Acta Biochimica et Biophysica Sinica》2010年第9期615-622,共8页Xueya Zhang Haobo Huang Zhenshu Xu Rong Zhan 
2-Methoxyestradiol （2-ME2） is an endogenous metabolite of 17β-estradioi （E2） with estrogen receptor-independent anti-cancer activity. The current study sought to determine the mechanism of anti-cancer activity of...
关键词：2-METHOXYESTRADIOL human acute T lymphoblastic leukemia cell proliferation cell apoptosis cell cycle 
Synthesis of 3-(4-hydroxyphenyl)-4-methyl-6-methoxy-7-hydroxycoumarin and its analogues as angiogenesis inhibitors
《Journal of Chinese Pharmaceutical Sciences》2010年第2期136-140,共5页邹昊 蒋皓 周洁芸 朱焰 曹霖 夏鹏 张倩 
National Natural Science Foundation(Grant No. 30500631).
3-（4-Hydroxyphenyl）-4-methyl-6-methoxy-7-hydroxycoumarin （2a） and its analogues with different substituents at the p-position of 3-phenyl group were designed and synthesized as the non-steroidal analogues of 2-met...
关键词：Angiogenesis inhibitor 2-METHOXYESTRADIOL Non-steroidal analogue 3-（4-Hydroxyphenyl）-4-methyl-6-methoxyl-7- hydroxycoumarin 
2-methoxyestradiol通过反应性氧基对U937白血病细胞的凋亡诱导作用
《吉林大学学报（医学版）》2008年第3期469-473,共5页佘妙容 郭坤元 牛新清 卢晓 涂三芳 
广东省科技厅自然科学基金资助课题(7001196);广东省卫生厅资助课题(A2006020)
目的:探讨2-ME诱导U937白血病细胞凋亡的作用和机制。方法:实验分为白血病细胞株U937细胞含有等量DMSO RPMI 1640培养液的对照组、2-ME处理组、NAC处理组和2-ME+NAC处理组。MTT测定评价对U937细胞毒作用;采用Annexin V和NO染料标记细胞...
关键词：白血病 2-methoxyestradi01 凋亡 反应性氧基 一氧化氮 超氧化物离子 
Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol被引量：1
《Acta Pharmacologica Sinica》2007年第7期1037-1044,共8页Miao-rong SHE Jing-gao LI Kun-yuan GUO Wei LIN Xin DU Xin-qing NIU 
Aim： To investigate the effects of 2-methoxyestradiol （2-ME） on 2 myeloid leukemia cell lines HL-60 and U937, and to explore its mechanisms. Methods： Human myeloid leukemia cells HL-60 and U937 were used. Measurem...
关键词：2-METHOXYESTRADIOL APOPTOSIS reactive oxygen species nitric oxide SUPEROXIDES LEUKEMIA 
2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells被引量：13
《Acta Pharmacologica Sinica》2004年第11期1515-1520,共6页Ning-ningZHOU Xiao-fengZHU Jun-mingZHOU Man-zhiLI Xiao-shiZHANG PengHUANG Wen-qiJIANG 
AIM: To investigate 2-methoxyestradiol induced apoptosis and its mechanism of action in CNE2 cell lines. METHODS: CNE2 cells were cultured in RPMI-1640 medium and treated with 2-methoxyestradiol in different concentra...
关键词：2-METHOXYESTRADIOL APOPTOSIS cell cycle nasopharyngeal neoplasms 
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