Supported by the National Natural Science Foundation of China(No.20576094)
A series of novel 7-amide substituted-4-androstene-3,17-dione derivatives(8αa "8αh or 8βa "8βh) was synthesized from the important intermediates 5 by N-acylation and acidic hydrolysis.Compounds 5α and 5β wer...
the Key Subject of Shanghai Municipal Education Commission(J50102);the Foundation of Education Commission of Shanghai Municipality(08zz44)
The reaction of hydrazine hydrate with a new α,γ-diketone ester 3, derived from the reaction of 2,6-dimethyl-3,5-diacetyl-pyridine 2 with diethyl oxalate in the presence of sodium ethoxide, afforded the pyrazole der...
Supposed by the National Natural Science Foundation of China
The reactions of 5-methyl-3-hydroxyisoxazole with 2, 2-dimethyl, 3-substituted cyclopropanecarboxylic chlorides give O-acyl-5-methyl-3-hydroxyisoxazole and N-acyl-5-methylisoxazolin-3-one derivatives. The ratio of O-a...
Acylation of 5-methyl-3-hydroxyisoxazole (1) with 3-substituted cyclopropanecarboxylic chlorides (3) in the presence of triethylamine (TEA) in acetonitrile yields predominantly O-acylated products (4).The N-acyl isom...