ANTITUMOR

作品数：470被引量：1206H指数：15
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相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>
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Luminescence-activated Pt(Ⅳ)prodrug for in situ triggerable cancer therapy
《Chinese Chemical Letters》2024年第7期383-387,共5页Huijie An Chen Yang Zhihui Jiang Junjie Yuan Zhongming Qiu Longhao Chen Xin Chen Mutu Huang Linlang Huang Hongju Lin Biao Cheng Hongjiang Liu Zhiqiang Yu 
supported by the National Natural Science Foundation of China(Nos.32201171 and 82372115);the Science and Technology Program of Guangzhou(No.202102021266)。
Anticancer platinum prodrugs that can be controllably activated are highly desired for personalized precision medicine and patient compliance in cancer therapy.However,the clinical application of platinum(Ⅳ)prodrugs(...
关键词：Tumor microenvironment Endogenous luminescence Platinum(Ⅳ)prodrug Activation strategy ANTITUMOR BIOSAFETY 
Rational design of platinum(Ⅱ)complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo
《Science China Chemistry》2023年第10期2878-2884,共7页Yeye Ai Zherui Zhang Yuexuan Fei Ruirong Ye Angela Sin-Yee Law Zong-Wan Mao Junqiu Liu Yongguang Li Vivian Wing-Wah Yam 
supported by Zhejiang Provincial Natural Science Foundation of China(LR22B010001,LQ23B010001);the National Natural Science Foundation of China(22201057,21871297);the General Research Fund(GRF)grant from the Research Grants Council of the Hong Kong Special Administrative Region,People’s Republic of China(HKU17303421);the Collaborative Research Fund(CRF)(C7075-21G);Hangzhou Normal University(2021QDL001,2021QDL065);the West Lake Scholar Plan,the Hangzhou Leading Innovation and Entrepreneurship Team Project(TD2022001);the CAS-Croucher Funding Scheme for Joint Laboratory on Molecular Functional Materials for Electronics,Switching and Sensing;support from Sun Yat-Sen University;The University of Hong Kong;the Innovation Technology Commission to the State Key Laboratory of Synthetic Chemistry。
The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer chemotherapy.Herein,the mitochondria-targeted platinum(Ⅱ)complexes have been prepared.The introduction of the tri...
关键词：platinum(Ⅱ)complexes post-click reaction emission enhancement mitochondria-targeting ANTITUMOR 
Design, synthesis and biological evaluation of a novel platinum(Ⅱ)complex possessing bioreductive groups for cancer therapy被引量：1
《Chinese Chemical Letters》2019年第1期243-246,共4页Chengken Chen Chunmei Gao Zigao Yuan Yuyang Jiang 
Shenzhen Sci & Tech Bureau (Nos. JCYJ20160301153959476 and JCYJ20160324163734374)
Cisplatin is one of the most successful antitumor agents, yet also restricted by its poor cellular uptake and low selectivity. Since 3-(2-nitrophenyl) propionic acid(NPPA) has been reported as a bioreductive prodrug m...
关键词：PLATINUM COMPOUNDS Bioreductive Nitrophenylalkanoic GROUP CELLULAR UPTAKE ANTITUMOR 
Current Status for Oral Platinum (IV) Anticancer Drug Development
《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》2018年第2期231-247,共17页Qian Mi Shunshun Shu Caixia Yang Chuan Gao Xian Zhang Xiao Luo Chonghuan Bao Xia Zhang Jun Niu 
Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of tumors. However, poor solubility, serious side effects, and more importantl...
关键词：PLATINUM (IV) COMPLEXES Properties Mechanism ANTITUMOR Activity Cancer THERAPY Photoactivatable 
THE CRYSTAL AND MOLECULAR STRUCTURE OF DIHYDROXY (MALONATO)-DIAMMINE PLATINUM (Ⅱ)
《Chinese Science Bulletin》1983年第2期200-205,共6页李根培 唐有祺 管荫桐 唐雯霞 戴安邦 
Ⅰ. INTRODUCTION A few platinum complexes having antitumor properties have attracted much interest in recent years, Now we have synthesized and tested the Pt(Ⅳ) malonato complex, which appears to exhibit significant ...
关键词：PLATINUM agonal subsequent REPORTING ANTITUMOR COMPLEXES MALONATO FITTING filtered longer 
PLATINUM COMPLEXES OF ISOPROPYLAMINE AND THEIR ACTIVITY AGAINST L-1210 IN BDF_1 MICE
《Chinese Science Bulletin》1983年第1期54-58,共5页唐雯霞 邵荣泉 管荫桐 周爱萍 戴安邦 籍秀娟 万家濂 
Ⅰ. INTRODUCTION Recently, the antitumor action of platinum compounds and the mechanism of the action have attracted wide attention. However, most of the studies are concerned with Pt(Ⅱ) complexes, and only a few of ...
关键词：dichloro complexes PLATINUM concerned ANTITUMOR SOLUBILITY inert readily initiated CISPLATIN 
A STUDY OF ANTITUMOR EFFECT OF PLATINUM COMPOUNDS (Ⅰ)
《Chinese Science Bulletin》1981年第4期351-356,共6页潘启超 刘宗潮 谢冰芬 唐雯霞 管荫桐 邵荣泉 
Recently, the research of the antitumor effect of platinum compounds has aroused wide attention. Cis-dichloro-diamine-platinum (DDP) is now used in clinical practice with good results. The antitumor and pharmacologica...
关键词：ANTITUMOR PLATINUM DIAMINE dichloro doses DOSAGE dihydroxy markedly TETRA valent 
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