SIMVASTATIN

作品数:146被引量:355H指数:10
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相关作者:赵慧刘树泰孙宏晨王渝臧光祥更多>>
相关机构:大连医科大学苏州大学吉林大学大连医科大学附属第二医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划大连市科技计划项目河北省自然科学基金更多>>
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Comparison of conventional and supported liquid extraction methods for the determination of sitagliptin and simvastatin in rat plasma by LC-ESI-MS/MS被引量:1
《Journal of Pharmaceutical Analysis》2015年第3期161-168,共8页B.Ramesh N.Manjula S.R.Bijargi V.U.M.Sarma P.Sita Devi 
Three extraction methods were compared for their efficiency to analyze sitagliptin and simvastatin in rat plasma by LC-MS/MS, including (1) liquid-liquid extraction (LLE), (2) solid phase extraction (SPE) and ...
关键词:Rat plasma SIMVASTATIN Sita#'ptin Supported liquid extraction 
Simultaneous determination of ezetimibe and simvastatin in rat plasma by stable-isotope dilution LC-ESI-MS/MS and its application to a pharmacokinetic study被引量:4
《Journal of Pharmaceutical Analysis》2014年第4期286-294,共9页Sireesha R.Karanam Prakash Katakam Babu R.Chandu Nagiat T.Hwisa Shanta K.Adiki 
A simple, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma. The deuterium isotopes: ezetimibe d4 an...
关键词:EZETIMIBE SIMVASTATIN PharmacokineticsRat plasma LC-ESI-MS/MS 
Validated LC-MS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate: Pharmacokinetic application
《Journal of Pharmaceutical Analysis》2012年第6期403-411,共9页Tamer A. Ahmed Jamie Horn John Hayslip Markos Leggas 
Simvastatin (SIM) is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor widely used in hyperlipidemia therapy. SIM has recently been studied for its anticancer activity at doses higher than those used for t...
关键词:SIMVASTATIN LC-MS/MS Human plasma Cell lysate PHARMACOKINETIC HIGH-DOSE 
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