EZETIMIBE

作品数:86被引量:156H指数:7
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相关领域:医药卫生更多>>
相关作者:赵秀丽王思明苏冰黄伟岑均达更多>>
相关机构:南华大学武汉大学首都医科大学上海医药工业研究院更多>>
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相关基金:国家自然科学基金北京市自然科学基金国家重点基础研究发展计划北京市科技新星计划更多>>
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Pharmacokinetics and Bioequivalence Comparison of Two Fixed-Dose Combination of Rosuvastatin/Ezetimibe Formulations: A Randomized, Crossover, Open-Label Study in Healthy Volunteers
《Journal of Biosciences and Medicines》2024年第10期119-139,共21页José Gregorio Chacón Evelyn Peña Alfredo Inatti 
Objective: To evaluate the bioequivalence (BE) of two fixed-dose combination (FDC) formulations of Rosuvastatin and Ezetimibe: Cresadex® EZE 20/10 mg (Abbott Laboratories) as the reference formulation (R), and Racor® ...
关键词:BIOEQUIVALENCE PHARMACOKINETICS ROSUVASTATIN EZETIMIBE FDC 
Lowering of Blood Lipid Levels with a Combination of Pitavastatin and Ezetimibe in Patients with Coronary Heart Disease: A Meta-Analysis
《Cardiovascular Innovations and Applications》2022年第4期41-55,共15页Ruping Cai Chen Chang Xingjie Zhong Qiang Su 
Objectives:According to the findings of randomized controlled trials,blood lipid levels in patients with coronary heart disease(CHD)can be significantly decreased through a combination of pitavastatin and ezetimibe;ho...
关键词:PITAVASTATIN EZETIMIBE Coronary heart disease Blood lipid 
Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model
《Gastroenterology Report》2022年第1期440-450,共11页Sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung Joo Cho Hye Jung Park Hye Won Lee Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Soo Han Bae Seung Up Kim 
supported by Daewoong Pharmaceutical company,and was supported by a Faculty Research Grant from the Yonsei University College of Medicine(6-2019-0068 to S.H.Bae);by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(HI17C0913 and HI16C0257 to S.H.Bae);supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(NRF-2022R1A2C2003438 to S.H.Bae,NRF-2021R1C1C2095694 to D.H.Lee);by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT&Future Planning(2019R1A2C4070136 to S.U.Kim).
Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix ...
关键词:non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid ROSUVASTATIN EZETIMIBE 
Is there a role of lipid-lowering therapies in the management of fatty liver disease?被引量:3
《World Journal of Hepatology》2022年第1期119-139,共21页Ismini Tzanaki Aris P Agouridis Michael S Kostapanos 
Atherogenic dyslipidemia is characterized by increased triglyceride-rich lipoproteins and low high-density lipoprotein cholesterol concentrations.It is highly prevalent in non-alcoholic fatty liver disease(NAFLD)and c...
关键词:Non-alcoholic fatty liver Non-alcoholic steatohepatitis STATIN EZETIMIBE FIBRATES ω-3 fatty acids Bile acid resins 
Lowering low-density lipoprotein cholesterol: from mechanisms to therapies被引量:3
《Life Metabolism》2022年第1期25-38,共14页Jie Luo Jin-Kai Wang Bao-Liang Song 
This work was supported by grants from the Ministry of Science and Technology(2018YFA0800703);the National Natural Science Foundation(91957103,31690102,32021003,and 91957208).B.-L.Song acknowledges the support from the Tencent Foundation through the XPLORER PRIZE.
Low-density lipoprotein(LDL)is the main carrier of cholesterol and cholesteryl ester in circulation.High plasma levels of LDL cholesterol(LDL-C)are a major risk factor of atherosclerotic cardiovascular disease(ASCVD)....
关键词:CHOLESTEROL low-density lipoprotein STATIN EZETIMIBE proprotein convertase subtilisin/kexin type 9 atherosclerotic cardiovascular disease 
Lipid lowering in patients 75 years and older
《World Journal of Cardiology》2021年第10期526-532,共7页Umidakhon Makhmudova P Christian Schulze Harry R Davis Oliver Weingartner 
More than twenty years ago,knowledge about the importance of cholesterol absorption and the potential therapeutic effect of its inhibition led to the discovery and clinical application of the first and only cholestero...
关键词:CHOLESTEROL Cholesterol absorption Cholesterol synthesis EZETIMIBE ELDERLY 
Intensive lipid-lowering therapy,time to think beyond low-density lipoprotein cholesterol被引量:1
《World Journal of Cardiology》2021年第9期472-482,共11页Ahmed Abdalwahab Ayman Al-atta Azfar Zaman Mohammad Alkhalil 
Statins have been shown to be effective in reducing cardiovascular events.Their magnitude of benefits has been proportionate to the reduction in low-density lipoprotein cholesterol(LDL-c).Intensive lipid-lowering ther...
关键词:Intensive lipid-lowering Proprotein convertase subtilisin kexin 9 inhibitors EZETIMIBE Plaque imaging Low-density lipoprotein cholesterol 
Analysis of the Efficacy and Clinical Safety of Atorvastatin Calcium Combined with Novel Ezetimibe in the Treatment of Coronary Heart Disease
《外文科技期刊数据库(文摘版)医药卫生》2021年第1期546-550,共5页LIU Chuanzhao 
Objective: to study the effect of atorvastatin calcium combined with ezetimibe in the treatment of coronary heart disease. Methods: From January to December 2020, 90 hospitalized patients with coronary heart disease w...
关键词:coronary heart disease atorvastatin calcium tablets novel fold wheat cloth sheet adverse reaction 
Bempedoic acid(Nexletol/Nexlizet)被引量:1
《中国药物化学杂志》2021年第1期80-80,共1页徐绍山(编译) 张美慧(审校) 
Bempedoic acid是美国Esperion公司研发的三磷酸腺苷柠檬酸裂解酶(ACLY)抑制剂。2020年2月21日,美国食品药品监督管理局(FDA)批准bempedoic acid上市,商品名为Nexletol,同时FDA批准了bempedoic acid和依折麦布(ezetimibe)的复方制剂,商...
关键词:家族性高胆固醇血症 依折麦布 三磷酸腺苷 动脉粥样硬化性心脑血管疾病 柠檬酸裂解酶 复方制剂 EZETIMIBE 
Intensive statin versus low-dose statin + ezetimibe treatment for fibrous cap thickness of coronary vulnerable plaques被引量:4
《Chinese Medical Journal》2020年第20期2415-2421,共7页Pei-Na Meng De-Lu Yin Wen-Qi Lu Tian Xu Wei You Zhi-Ming Wu Xiang-Qi Wu Fei Ye 
a grant from the Nanjing Medical Science and Technology Development Foundation,Nanjing Department of Health(No.201803008).
Background:Acute coronary syndromes mainly result from abrupt thrombotic occlusion caused by atherosclerotic vulnerable plaques (VPs) that suddenly rupture or erosion. Fibrous cap thickness (FCT) is a major determinan...
关键词:STATINS EZETIMIBE Fibrous cap thickness Coronary vulnerable plaques Optical coherence tomography 
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