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Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
《Cell Research》2024年第12期859-872,共14页Ting Zhao Xueying Guan Yan Hu Ziqian Zhang Han Yang Xiaowen Shi Jin Han Huan Mei Luyao Wang Lei Shao Hongyu Wu Qianqian Chen Yongyan Zhao Jiaying Pan Yupeng Hao Zeyu Dong Xuan Long Qian Deng Shengjun Zhao Mengke Zhang Yumeng Zhu Xiaowei Ma Zequan Chen Yayuan Deng Zhanfeng Si Xin Li Tianzhen Zhang Fei Gu Xiaofeng Gu Lei Fang 
This work was financially supported in part by grants from the Biological Breeding-Major Projects(2023ZD04076);the National Natural Science Foundation of China(32341024);Fundamental Research Funds for the Central Universities(226-2022-00100;226-2024-00205);the Alibaba-Zhejiang University Joint Research Institute of Frontier Technologies.
DNA methylation plays multiple regulatory roles in crop development.However,the relationships of methylation polymorphisms with genetic polymorphisms,gene expression,and phenotypic variation in natural crop population...
关键词：breeding alone COTTON 
Identification of SNPs involved in regulating a novel alternative transcript of P450 CYP6ER1 in the brown planthopper被引量：2
《Insect Science》2018年第5期726-738,共13页Zhi-Kun Liang Rui Pang Yi Dong Zhong-Xiang Sun Yan Ling Wen-Qing Zhang 
We thank Dr. Jianming Chen （Zhejiang Academy of Agri- cultural Sciences, Hangzhou, China） for providing the susceptible population and Jiaxing field-collected pop- ulation, and Dr. Ping Wang （Cornell University, USA） for his critical comments on this manuscript. This work was funded by the National Basic Research Program of China （Grant 2010CB 126200）, National Natural ScienceFoundation of China （U 1401212） and the China Postdoc- toral Science Foundation （2016M602582）.
Cytochrome P450-mediated metabolic resistance is one of the major mecha- nisms involved in insecticide resistance. Although the up-regulation of cytochrome P450 plays a vital role in insecticide metabolism, the molecu...
关键词：alternative splicing cytochrome P450 Nilaparvata lugens single nucleotidepolymorphisms （SNPs） transcription factor binding 
Association between well-characterized lung cancer IncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer被引量：10
《Acta Pharmacologica Sinica》2017年第4期581-590,共10页Wei-jing GONG Jing-bo PENG Ji-ye YIN Xiang-ping LI Wei ZHENG Ling XIAO Li-ming TAN Di XIAO Yi-xin CHEN Xi LI Hong-hao ZHOU Zhao-qian LIU 
This work was supported by the National Key Research and Development Plan （SQ2016YFSF110100 and 2016YFC0905000）, National Natural Science Foundation of China （81373490, 81573508, and 81573463）, Hunan Provincial Science and Technology Plan of China （2015JC3025）, and Open Foundation of Innovative Platform in University of Hunan Province of China （421530004）.
Platinum-based chemotherapy is the standard first-line treatment for most lung cancer patients. However, the toxicity induced by platinum-based chemotherapy greatly impedes its clinical use. Previous studies showed ...
关键词：lung cancer platinum-based chemotherapy gastrointestinal toxicity hematological toxicity long non-coding RNA （IncRNA） POLYMORPHISM Chinese patients 
Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke被引量：40
《Acta Pharmacologica Sinica》2016年第7期882-888,共7页Rui LIU Zi-yi ZHOU Yi-bei CHEN Jia-li LI Wei-bang YU Xin-meng CHEN Min ZHAO Yuan-qi ZHAO Ye-feng CAI Jing JIN Min HUANG 
Aim： There is a high incidence of the antiplatelet drug clopidogrel resistance （OR） in Asian populations. Because clopidogrel is a prodrug, polymorphisms of genes encoding the enzymes involved in its biotransformat...
关键词：clopidogrel resistance ischemic stroke genotype analysis SNPS CYP3A4＊1G NR112 CYP2C19＊2 P2RY12 PHARMACOGENOMICS 
Association of polymorphisms of A260G and A386G in DAZL gene with male infertility： a meta-analysis and systemic review被引量：3
《Asian Journal of Andrology》2016年第1期96-101,共6页Ping Chen Xiao Wang Chang Xu He Xiao Wen-Hao Zhang Xing-Huan Wang Xin-Hua Zhang 
ACKNOWLEDGMENTS XHZ is supported by the National Natural Science Foundation of China （No. 81270843 and No. 81160086）.Supplementary information is linked to the online version of the paper on the Asian Journal of Andrology website.
To investigate the association of single nucleotide polymorphism 260 and 386 （SNP260 and SNP386） gene with male infertility, an electronic search was performed to identify case-control studies evaluating the relatio...
关键词：deleted in azoospermia-like male infertility META-ANALYSIS POLYMORPHISM single nucleotide polymorphisms 
Apal, Bsml, Fokl, and Taql Polymorphisms in the Vitamin D Receptor Gene and Parkinson＇s Disease被引量：7
《Chinese Medical Journal》2015年第13期1809-1814,共6页Meng-Yue Niu Lei Wang An-Mu Xie 
a grant from the Natural Science Foundation of Shandong Province,China
Background： The vitamin D receptor （VDR） gene has been identified as a candidate gene liar susceptibility to Parkinson＇s disease （PD）, but results from genetic association studies to date are inconsistent. Here,...
关键词：Metaianalysis Parkinson＇s Disease Polyrnorphism Vitamin D Receptor 
Association of polymorphisms in glutathione S-transferase genes （GSTM1, GSTT1, GSTP1） with idiopathic azoospermia or oligospermia in Sichuan, China被引量：5
《Asian Journal of Andrology》2015年第3期481-486,共6页Da-Ke Xiong 
The reported effects of the glutathione S-transferase （GSTs） genes （GSTM1, GSTTI, and GSTP1） on male factor infertility have been inconsistent and even contradictory. Here, we conducted a case-control study to inv...
关键词：genetic polymorphism glutathione S-transferase idiopathic infertility male factor 
Association of positively selected elF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients被引量：3
《Acta Pharmacologica Sinica》2015年第3期375-384,共10页Ji-ye YIN Xiang-guang MENG Chen-yue QIAN Xiang-ping LI Juan CHEN Yi ZHENG Rong LIU Hong-hao ZHOU Zhao-qian LIU 
Aim： Eukaryotic translation initiation factor 3 subunit A （elF3a） plays critical roles in regulating the initiation of protein translation, and elF3a is highly expressed in lung cancer. In this study, we investigat...
关键词：elF3a positive selection POLYMORPHISM lung cancer platinum-based chemotherapy chemotherapy toxicity Chinese NSCLC patients 
Association between vitamin D receptor polymorphisms and multiple sclerosis： systematic review and meta-analysis of case-control studies被引量：9
《Cellular & Molecular Immunology》2015年第2期243-252,共10页Kalthoum Tizaoui Wajih Kaabachi Agnes Hamzaoui Kamel Hamzaoui 
Vitamin D receptor （VDR） polymorphisms have been studied as potential contributors to multiple sclerosis （MS）. However, published studies differ with respect to study design and the significance of the effects det...
关键词：Apal Bsml Fokl META-ANALYSIS multiple sclerosis Taql VDR polymorphism 
Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population被引量：12
《Acta Pharmacologica Sinica》2014年第11期1421-1427,共7页Xue SUN Feng JIANG Rong ZHANG Shan-shan TANG Miao CHEN Dan-feng PENG Jing YAN Tao WANG Shi-yun WANG Yu-qian BAO Cheng HU Wei-ping JIA 
Acknowledgements We thank all participants of this research. We thank the nursing and medical staff at the Shanghai Clinical Center for Diabetes for their dedication to this study. We acknowledge grants from National Natural Science Foundation of China （No 81322010）, Excellent Young Medical Expert of Shanghai （No XYQ2011041）, the Shanghai Rising Star Program （No 12QH!401700）, the Shanghai Talent Development Grant （No 2012041） and the National Program for Support of Top-notch Young Professionals.
Aim： Genome-wide association studies have identified several novel loci associated with serum uric acid concentrations in individuals of European descent. In the current study, we aimed to evaluate the associations b...
关键词：uric acid GOUT single nucleotide polymorphisms SLC2A9 SF1 GCKR genome-wide association Chinese 
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