The effects of leptin on cytotrophoblast proliferation and invasion activity were investigated. Immunohistochemistry was used to determine the placental expression of leptin in first-trimester pregnancy. By using RT-P...
Objective To investigate the effect of Traditional Chinese Medicine(TCM) on the growth and invasion of human first trimester cytotrophoblasts in vitro.Methods Serum contained drug was collected from rats adiminister...
Background Enhanced apoptosis of cytotrophoblasts in early pregnancy is associated with high risk of intrauterine growth retardation and preeclampsia, which are two common pregnant complications. Its etiological facto...
This work was supported by the Special Funds for the Major State Basic Research Project (Grant No. G1999055903);the Climbing Project of China (Grant No. 970211019-3);the Hundred-Scientist-Program of the Chinese Academy of Sciences.
There are striking similiarities present between the behavior of invasive placentaL cells and that of invasive cancer cells. Matrix metalloproteinases (MMPs) are one of the most important mediators. MMP-28, the new me...
A new method of long-term culture of cytotrophoblast cells in serum-free medium has been developed. Cytotrophoblast cells were isolated with cold trypsin and purified by unit gravity sedimentation through BSA density ...