Supported by the National Technology-Innovation Fund(No.02CJ-13-01-16);the Open Fund of State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University, China
Lacosamide was prepared by chemical method coupled with enzymatic method. N-Acetyl-D, L-3-methoxy-alanine, derived from D,L-3-methoxy-alanine, was used in the resolution process catalyzed by immobilized Escherichia co...