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Establishment of a humanized ST6GAL1 mouse model for influenza research
《Animal Models and Experimental Medicine》2024年第3期337-346,共10页Lyu Chao Han Feng Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan Hu Yuechao Yang Mengjie Zhao Yingze Liu Jun Lu Xuancheng Duo Shuguang 
National Key Research and Development Program of China,Grant/Award Number:2021YFC2301403 and 2022YFF0711000。
Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encodi...
关键词：hST6GAL1 humanized mice influenza animal model 
Progress,implications,and challenges in using humanized immune system mice in CAR-T therapy-Application evaluation and improvement
《Animal Models and Experimental Medicine》2024年第1期3-11,共9页Hanwei Yue Lin Bai 
CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-035;National Key Research and Development Project,Grant/Award Number:2022YFA1103803。
In recent years,humanized immune system(HIS)mice have been gradually used as models for preclinical research in pharmacotherapies and cell therapies with major breakthroughs in tumor and other fields,better mimicking ...
关键词：ANTITUMOR ANTIVIRAL CAR-T humanized immune system model humanized mice preclinical research 
Development of a humanized HLA-A30 transgenic mouse model被引量：7
《Animal Models and Experimental Medicine》2022年第4期350-361,共12页Meng-min Zhu Bo-wen Niu Ling-ling Liu Hua Yang Bo-yin Qin Xiu-hua Peng Li-xiang Chen Yang Liu Chao Wang Xiao-nan Ren Chun-hua Xu Xiao-hui Zhou Feng Li 
supported by the followed funds:National Science and Technology Major Project(2017ZX10304402-001-006,2017ZX10304402-001-012,2016YFD0500208);Shanghai Science and Technology Commission“R&D public service platform and institutional capacity improvement project”(21DZ2291300);Shanghai scientific research projects(19140905300);Shanghai Public Health Clinical Center projects(KY-GW-2019-11,KY-GW-2019-19,and KY-GW-2021-39)。
Background:There are remarkable genetic differences between animal major histocompatibility complex(MHC)systems and the human leukocyte antigen(HLA)system.HLA transgenic humanized mouse model systems offer a much bett...
关键词：HLA-A30 humanized mouse IMMUNOLOGY major histocompatibility complex(MHC) 
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