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M-HT was supported by the Strategic Priority Research Pro- gram of the Chinese Academy of Sciences (XDB19000000), the Ministry of Science and Technology of China (2014CB943101), the National Key Research and Development Program of China (2016YFC1000600), SIBS foundation, the National Natural Science Foundation of China (31471401 and 31671553), the Science and Technology Commission of Shanghai Municipality (14140901502 and 14JC1407100). This work was also supported by NIH HG008688 (CH). CH is an investigator of the Howard Hughes Medical Institute. XY was supported by the National Natural Science Foundation of China (81472855 and 91540109), the Ministry of Science and Technology of China Grant (2016YFC0906001). We thank the Histology, Flow Cytometry and Vivarium services at SIBCB, and the Genome Sequencing and High-performance Computing services from the National Protein Science Facility (Beijing) at Tsinghua University.
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells (SSCs) produce hap- loid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, postt...
We thank Drs Narry Kim (Seoul National University, Korea) and Fatitima Gebauer (Centre for Genomic Regulation, Spain) for suggestions and critical comments on the manuscript; Drs Chen Chu, Junhao Li, and Xianghua Piao for experimental and bioinformatic assistance. This work was supported by grants from the Ministry of Science and Technology of China (2011CB811303, 2014CB964802, 2014CB943103, 2012CB910803), the National Natural Science Foundation of China (31325008, 91219306, 31270840, 31170754, 31300656), and Science and Technology Commission of Shanghai Municipality (13ZR 1464300).
Spermatogenesis in mammals is characterized by two waves of piRNA expression: one corresponds to classic piR- NAs responsible for silencing retrotransponsons and the second wave is predominantly derived from nontrans...
the National Basic Research Program(973 Program)(Nos.2012CB945002 and 2010CB912303)and 31171337 from the Chinese government.
The dynamic polar polymers actin fi laments and microtu-bules are usually employed to provide the structural ba-sis for establishing cell polarity in most eukaryotic cells.Radially round and immotile spermatids from n...
supported by the National Basic Research Program of China(Nos.2012CB94502,2010CB912303)(to L.M.);the National Natural Science Foundation of China(Grant Nos.31171337 and 30971648)(to L.M.);Grant Nos.30871226 and 31071180(to Y.Z.);supported by the Chinese Academy of Sciences 100-Talents Program.
Nematode sperm undergo a drastic physiological change during spermiogenesis(sperm activation).Unlike mammalian flagellated sperm,nematode sperm are amoeboid cells and their motility is driven by the dynamics of a cyto...
This work was supported by the National Key Basic Research Project (Grant No. G1999055901).
The differentiation process of round spermat-ids to spermatozoa during the late stage of spermatogenesis is called spermiogenesis. To explore spermiogenesis-related genes, cDNA microarray was used to study expression ...