Mitophagy, or mitochondria autophagy, plays a critical role in selective removal of damaged or unwanted mitochondria. Several protein receptors, including Atg32 in yeast, NIX/BNIP3L, BNIP3 and FUNDCI in mammalian syst...
The directional migration of neutrophils towards inflammatory mediators, such as chemokines and cannabinoids, occurs via the activation of seven transmembrane G protein coupled receptors (7TM/GPCRs) and is a highly ...
Acknowledgments We thank Dr Morgan Sheng (Harvard University, USA) for providing the cDNA construct for PSD-95. This study was sup- ported by the Natural Science Foundation of China (30770662, 30825042); Hi-Tech Research and Development Program of China (2007AA02Z163), National Basic Research Program (2009CB2200) to XZ, and funding from the National Institutes of Health (REY016754A) and the American Heart Association (0665201Y) to JZ. Part of this work was conducted in a facility constructed with support from Research Facilities Improvement Program Grant C06-RR-12088-01 from the National Center for Research Resources.
The present study aims to define the role of postsynaptic density (PSD)-95 in the regulation of dopamine (DA) receptor function. We found that PSD-95 physically associates with either D1 or D2 DA receptors in co-t...