STAPHYLOKINASE

作品数：3被引量：10H指数：2
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相关机构：中国科学院更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》更多>>
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Effect of site-specific PEGylation on the fibrinolytic activity, immunogenicity, and pharmacokinetics of staphylokinase被引量：1
《Acta Biochimica et Biophysica Sinica》2014年第9期782-791,共10页Jianwei Liu Zhu Wang Jintian He Gaizhen Wang Rongbo Zhang Baohua Zhao 
The bacterial plasminogen-activator staphylokinase （Sak） is a promising thrombolytic agent for treating acute myocar- dial infarction. To effectively reduce the immunogenicity of Sak while maintaining its fibrinolyt...
关键词：STAPHYLOKINASE site-specific pEGylation IMMUNOGENICITY PHARMACOKINETIC fibrinolytic activity 
Simultaneous elimination of T- and B-cell epitope by structure-based mutagenesis of single Glu80 residue within recombinant staphylokinase被引量：3
《Acta Biochimica et Biophysica Sinica》2010年第3期209-215,共7页Jintian He Ruiguang Xu Xi Chen Kai Jia Xianglian Zhou Ke Zhu 
To reduce the immunogenicity of recombinant staphyloki- nase, structure-based mutagenesis of Glu80 residue in wild-type staphylokinase （wt-Sak） was rationally designed and carried out by a modified QuikChange site-d...
关键词：STAPHYLOKINASE T-cell epitope B-cellepitope IMMUNOGENICITY fibrinolytics protein engineering 
Construction and Characterization of Novel Staphylokinase Variants with Antiplatelet Aggregation Activity and Reduced Immunogenecity被引量：7
《Acta Biochimica et Biophysica Sinica》2004年第5期336-342,共7页Hua-BoSU Yu-GaoZHANG Jin-TianHE WeiMO Yan-LingZHANG Xian-MeiTAO Hou-YanSONG 
To develop target thrombolytic agents with fibrinolytic activity, antiplatelet aggregation activity and reduced immunogenicity, two staphylokinase variants containing Arg-Gly-Asp (RGD) motif were constructed. ...
关键词：STAPHYLOKINASE RGD antiplatelet aggregation IMMUNOGENICITY 
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